lOW] 



Action of Vaeious Diuretics 



39 



while the remaining two dogs, young adults, as accurately as 

 could be ascertained, were about one year and two months old. 



The animals were given daily a known and constant quantity 

 of water and allowed a mixed diet of bread and raw meat. Fol- 

 lowing the preliminary period of observation of three days, they 

 were given subcutaneously on two successive days 6.7 mgs. of 

 uranium nitrate per kilogram. The two young adult animals re- 

 ceived 500 cc. of water daily, while the other members of the 

 group received 400 cc. 



On the second day of the uranium injections these animals 

 showed the following changes in output and in composition of 

 the urine: 



As will be seen from table 1, these animals, following the 

 development of a glycosuria, became polyuric. The output of 

 glucose, especially by the puppies, is remarkably constant for the 

 different animals, while the presence of acetone varies. The 



TABLE I 



quantity of acetone in the urine of these young animals is ex- 

 ceedingly small and its detection would frequently have been 

 missed without a microscopic examination of the tested distillate 

 for the presence of crystals of iodoform. 



The group of animals referred to as " adult " animals were 

 kept on the same diet as the younger animals, and like the 

 younger animals were given 6.7 mgs. of uranium nitrate per 

 kilogram on two successive days. The changes in the output of 

 urine and in the composition of the urine are indicated in table 

 2, which represents the course of eight characteristic experi- 

 ments following the uranium injections and prior to the use of 

 an anesthetic. 



