40 



Journal of the Mitchell Society 



[June 



table II 



A comparison of 'the two taWes showing the results obtained 

 in these groups of animals, representing different age limits, 

 shows in the first place, that the polyuria which, as has been pre- 

 viously stated, becomes pronounced with the development of the 

 glycosuria. The animals of the adult group show a higher de- 

 gree of polyuria than do the younger animals ; and they also 

 show, with one exception, a uniformly higher percentage of 

 glucose. 



Although quantitative determinations of acetone were not 

 made, we feel reasonably certain that the acetone output in 

 the adult animals was dictinctly in excess of that of the younger 

 animals. Judging from the density of the precipitate of albu- 

 men the same statement may be made for this element of the 

 urine. 



The microscopic examination of the centrifugalized urines in- 

 variably showed that in the adult animals casts were far more 

 numerous that in the young animals. The increase in the num- 

 ber of fatty casts was especially noticeable. 



From the foregoing observations, the following deductions ap- 

 pear allowable: 



1. Uranium nitrate when given subcutaneously in the dose of 

 6.7 mgs. per kilogram induces in the dog a series of changes 

 which vary in their degree of severity. 



2. The severity of these changes is determined by the age of 

 the animal, the changes being more pronounced in adult animals 

 and less pronounced in young animals. 



3. The factors which determine these differences in the 



