42 Journal of the Mitchell Society [June 



half hour period that the animal was under observation after the com- 

 pletion of the operation the output of urine was 2.7 cc. Following this 

 period of diuresis the animal became completely anuric, and with the de- 

 velopment of the anuria the struggling and other evidences of an imper- 

 fect anesthesia ceased. , , 



At the commencement of the experiment the animal had a blood pres- 

 sure of 105 mm. of mercury, and at its termination a blood pressure of 

 165 mm. of mercury. At no time during the experiment was there evi- 

 dence of any over action of the anesthetic. The animal remained com- 

 pletely anuric to caffeine, theobromine, digitalin, 0.9 per cent sodium chlo- 

 ride and 2 per cent sodium chloride. The experiment shows that even 

 though an adult animal may not be completely anuric at the commence- 

 ment of an experiment, the changes in the kidney which are inaugurated 

 by the anesthetic, progress with the anesthesia, and that with the develop- 

 ment of a state of satisfactory surgical anesthesia an adult animal which 

 has been anesthetized by Grehant's anesthetic becomes anuric. 



The young animals and puppies that had been rendered ne- 

 phritic, glycosuric, and polyuric by the same quantity of uran- 

 ium per kilogram that was employed for the adult animals, 

 showed after the administration of Grehant's anesthetic in 60 

 per cent strength a distinct difference in the effect of the anes- 

 thetic on the output and composition of the urine. 



Although this group of young animals received the same 

 quantity of Grehant's anesthetic and although they were allowed 

 the same time in which to develop the anesthesia, they were not 

 so completely anesthetized at the expiration of this period as 

 were the adult animals. It was usually necessary to give these 

 animals a small quantity of ether to complete the anesthesia. 

 After a satisfactory state of anesthesia had been established, it 

 was rarely necessary to administer the ether again. The ani- 

 mals remained satisfactorily anesthetized throughout the ex- 

 periment, which usually lasted several hours. 



The animals of this group show a distinct difference in the 

 effect of the anesthetic on the urine flow. l!^one of the members 

 of the group were rendered anuric by the anesthetic, but, on the 

 other hand, they were distinctly diuretic before and after the 

 introduction of various diuretic substances. 



The urine of this group of diuretic animals showed after 

 the anesthetic an increase in the quantity of glucose and in 

 those animals in which acetone was not present in the urine 



