IQIJ/.^ Action of Various Diuketics 43 



prior to the anesthetic, after the anesthetic, acetone was in- 

 variably present. 



The observation that has been made relative to the increase 

 in the quantity of glucose in the urine after the anesthetic might 

 be questioned on the ground that the increase in glucose was a 

 relative rather than an absolute increase, e. g., that with the 

 animals not so diuretic after the anesthetic as they were before 

 the fact that the urine became more concentrated would show a 

 rise in the percentage of glucose. 



To eliminate this possibility a series of normal animals were 

 given Grehant's anesthetic, and the changes induced in the com- 

 position of the urine were noted. (3) Following the anesthetic 

 these animals developed a glycosuria, the percentage of glucose 

 varying with the age of the animals. It seems therefore allow- 

 able to conclude that when Grehant's anesthetic is given to a 

 glycosuric animal the increase in the percentage of glucose in the 

 urine is an absolute rather than a relative increase. 



The following experiment will serve to show the difference in 

 the output and composition of the urine in a young animal from 

 that of the previously discussed adult animals. 



Experunent 18. The animal was receiving 400 cc. of water daily. 

 On the day of the experiment the output of urine was 780 cc. The urine 

 contained 0.446 per cent glucose but no acetone. Following the anesthetic, 

 the gluecose increased to 0.99 per cent and an acetonuria developed. At 

 the completion of the operation this animal had a blood pressure of 111 

 mm. of mercury and a urine flow of 1.4 cc. per ten minute interval. 



During the course of the experiment, which lasted for three and a 

 a half hours, the animal was completely anesthetized and was freely 

 diuretic to caffeine, digitalin and 0.9 per cent sodium chloride. At the 

 termination of the experiment the animal had a blood pressure of 118 mm. 

 of mercury and a urine flow of 4.5 per ten minute interval. 



THE EFFECT OF MOEPHINE-ETHEE ON THE OUTPUT AND COMPOSI- 

 TION OF THE UKINE IN YOUNG AND ADULT ANIMALS 



The young animals which received this type of anesthetic 

 showed but slight differences in the output and composition of 

 the urine and in their response to diuretics from the young ani- 

 mals receiving Grehant's anesthetic. The following experiment 

 shows the similarity in the response of these animals to mor- 

 phine-ether. 



