44 Journal, of the Mitchell Society [June 



Bxperiment 17. The animal was completely anesthetized. Prior to 

 the anesthetic the animal was receiving 400 cc. of water. On the day 

 of the experiment the animal had an output of urine of 790 cc. The urine 

 contained 0.202 per cent of glucose and was free from acetone. Fol- 

 lowing the anesthetic the animal remained diuretic and had an output 

 of urine of 2 cc. per ten minute interval before the use of any diuretic sub- 

 stance. During the course of the experiment the animal remained diuretic 

 to caffeine and digitalin. The urine collected showed an increase in 

 glucose to 0.501 per cent. The urine contained acetone. 



The adult animals which were given morphine-ether differed 

 from the adult animals receiving Grehant's anesthetic in that 

 thej did not become anuric, but remained responsive to the 

 same diuretic substances which when employed in animals anes- 

 thetized by Grehant's anesthetic were found to have no diuretic 

 value. 



Two very old animals that were nephritic from uranium 

 which were given morphine-ether, became anuric and the anuria 

 was uninfluenced by caffeine, digitalin and 0.9 per cent sodium 

 sulphate. These animals showed a pathological response on the 

 part of the kidney which was similar to the pathology which 

 develops in adult animals following Grehant's anesthetic and 

 which renders the animal anuric. 



The following experiment shows the usual effect of morphine- 

 ether as an anesthetic in adult animals : 



Bxperiment 16. The animal was receiving 500 cc. of water daily. On 

 the day of the experiment the output of the urine was 1015 cc. The urine 

 contained 1.22 per cent of glucose. Acetone was present. 



Following morphine-ether, which resulted in a complete anesthesia, the 

 animal remained diuretic. During the first ten minute period, before the 

 use of any diuretic substance, the output of urine was 3.4 cc. The animal 

 was diuretic to both caffeine and digitalin. The urine obtained during the 

 experiment showed an increase in glucose to 2.77 per cent. 



CONCLUSIONS CONCEENING THE EFFECT OF GEEHANt's ANES- 

 THETIC OF MORPHINE-ETHEE UPON THE OUTPUT AND THE 

 COMPOSITION OF THE UEINE IN YOUNG AND IN ADULT 

 DOGS NEPHEITIC FEOM UEANIUM 



1. When given to adult animals, Grehant's anesthetic pro- 

 duces a state of anuria which is uninfluenced by any of the 

 diuretic substances that have been employed in this investi- 

 gation. 



