191Jt-~\ Action of Various Diuretics 45 



2. When Grehant's anesthetic is given to young animals, the 

 animals remain diuretic and responsive to the various diu- 

 retic substances. The urine collected during the anesthesia 

 shows an increase in glucose over that induced by the injections 

 of uranium before the anesthetic. 



3. Adult animals when given morphine-ether have only occa- 

 sionally developed an anuria. The animals in our series which 

 have developed this condition have been old animals. In the 

 animals anuric from morphine-ether the changes in the kidney 

 are similar to those found in the kidneys of the animals anuric 

 from Grehant's anesthetic. 



In general, the adult animals anesthetized with morphine- 

 ether remain diuretic and are responsive to the different diuretic 

 substances. The urine shows an increase in the percentage of 

 glucose. 



4. The young animals anesthetized with morphine-ether have 

 without exception remained freely diuretic throughout the ex- 

 periments. The urine collected during the experiments has 

 shown a slight increase in the percentage of glucose. This in- 

 crease, however, is less than the increase observed in the adult 

 animals under the influence of the same anesthetic. 



5. In conclusion, the age of the animal apparently exerts some 

 influence over the toxicity of the anesthetic as did the same 

 factor influence the toxicity of the uranium prior to the anes- 

 thetic. 



THE EFFICIENCY OF VARIOUS DIURETICS IN URANIUM NEPHRITIS 



IN" ANIMALS ANESTHETIZED WITH GREHANT''s ANESTHETIC 



AND WITH MORPHINE-ETHER 



The efficiency of various diuretics in animals anesthetized luith 

 Grehant's anesthetic 



In considering the efiiciency of these different diuretic sub- 

 stances in animals anesthetized with Grehant's anesthetic, the 

 nephritic animals, so far as their response to the diuretics is 

 concerned, are found to arrange themselves into two groups: a 

 diuretic group which is represented by the young animals ; and 

 an anuric group which consists of adult animals which had re- 



