46 Journal op the Mitchell, Society \_June 



ceived the same quantity of the nephrotoxic substance per kilo- 

 gram and the same amount of the anesthetic per kilogram as was 

 received by the young animals. 



In these animals the following diuretic substances were em- 

 ployed: caffeine, theobromine, digitalin, 0.9 per cent and 2 per 

 cent sodium chloride, 0.9 per cent and 2 per cent sodium car- 

 bonate, 0.9 per cent sodium sulphate, and 0.9 per cent lithium 

 chloride. 



When these substances were employed in adult animals ne- 

 phritic from uranium and anuric from Grehant's anesthetic, 

 they had no diuretic value. After having once become anuric 

 these animals remained anuric. 



The following experiments are representative of this group 

 and demonstrate the inefficiency of substances as diuretics which 

 in a normal animal or in a nephritic animal which has not be- 

 come anuric, usually induce a distinct diuresis. 



Experiment 12. On the day of the experiment this animal had an 

 output of urine of 980 cc. Following Grehant's anesthetic the animal be- 

 came completely anuric and remained anuric throughout the experiment. 

 Cafifeine induced a rise in general blood pressure of from 125 to 140 mm. 

 of mercury without any change in kidney blood pressure. Digitalin in- 

 duced a rise in general blood pressure of from 130 to 140 mm. of mercury 

 with a rise in kidney blood pressure of 6 mm. of water. Sodium carbonate 

 in 2 per cent solution, given in the quantity of 10 cc. per kilogram, caused 

 a rise in general blood pressure of 13 mm. of mercury and a rise in kidney 

 blood pressure of 16 mm. of water. The animal received 175 cc. of salt 

 solution. 



Experiment 7. This animal during the first half hour period of ob- 

 servation was diuretic. Following this initial stage of diuresis the animal 

 became completely anuric and remained anuric, uninfluenced by the 

 diuretics. 



The animal's general blood pressure varied between 105 mm. of mer- 

 cury at the commencement of the experiment to 165 mm. of mercury 

 at its termination. At the commencement of the experiment the oncometer 

 showed a kidney pressure of 25.3 cm. of water and at the termination a 

 pressure of 32 cm. Cafifeine induced a rise in blood pressure of 32 mm. 

 of mercury and a rise in oncometer pressure of 16 mm. of water. Digitalin 

 increased the general blood pressure of 30 mm. of mercury, and the on- 

 cometer pressure 27 mm. of water, 0.9 per cent sodium chloride, 10 cc. 

 per kilogram gave a rise in general blood pressure of only 5 mm. of 

 mercury, while the oncometer showed an increase in pressure of 48 mm. 

 of water, 2 per cent sodium chloride in the quantity of 10 cc. per kilogram 



