19141 Action of Various Diuretics 47 



caused a rise in general blood pressure of 17 mm. of mercury and a rise 

 in kidney blood pressure of 27 mm. of water. The animal received 248 cc. 

 of salt solution. 



With the employment of other diuretic solutions in this group 

 of anuric animals, such for instance as sodium sulphate and 

 lithium chloride in 0.9 per cent solution, the same type of re- 

 sponse was obtained in general blood pressure changes and in 

 the local vascular changes in the kidney as were obtained from 

 the salt solutions just described. ISTeither the type of salt nor 

 the difference in the tonicity of the solutions which were em- 

 ployed induced any diuretic effect. 



The following series of animals which did not became anuric 

 from Grehant's anesthetic were young animals. Prior to the 

 anesthetic they had been rendered nephritic by the same 

 quantity of uranium per kilogram as was received by the adult 

 animals ; and later they received the same quantity of the anes- 

 thetic per kilogram as was received by the adult animals. 



With this group of animals the experiments were conducted 

 in a manner identical with the group just discussed; the same 

 diuretic substances were employed ; and they were given to the 

 animals in this same quantity per kilogram. 



The following series of animals which did not become anuric 

 retic response of the two groups. 



Experiment 18. The animal before the use of a diuretic had a flow of 

 urine of 1.4 cc. per ten minute interval. Following caffeine, which in- 

 duced a rise in general blood pressure of 6 mm. of mercury and in on- 

 cometer pressure of only 6 mm. of water, the urine flow increased to 2.S 

 cc, digitalin produced a rise in general pressure of 6 mm. of mercury 

 and in oncometer pressure of 15 mm. of water. The urine flow was in- 

 creased from 1.1 to 1.7 cc. per ten minute interval, following 0.9 per cent 

 sodium chloride, which induced practically no change in general blood 

 pressure but a rise in kidney blood pressure of 23 mm. of water; the urine 

 flow increased from 2 to 4.5 cc. 



A comparative study of these two groups of experiments in 

 which the animals received Grehant's anesthetic and in which 

 one group becomes anuric and fails to respond to diuretics, while 

 the other group does not become anuric and does respond to 

 diuretics, fails to show any variations in the changes in general 

 blood pressure which could account for the difference in the out- 

 put of urine. 



