48 Journal of the Mitchell, Society [June 



The changes in the oncometer pressure in the two groups show 

 that the kidney vessels are responsive to substances acting 

 peripherally on these vessels and that they also respond to 

 changes in the general circulation. A general analysis, how- 

 ever, of the pressure changes in the kidney induced by the dif- 

 ferent diuretics in the two groups of animals shows that in the 

 diuretic animals the changes in the kidney pressure are usually 

 more pronounced than they are in the anuric animals. At the 

 present time experiments are being conducted with the object in 

 view of determining whether or not there is any constant differ- 

 ence in the vascular response of the kidney vessels in the two 

 types of animals. 



The difference in the renal pathology of animals anuric and 

 diuretic following Grehant's anesthetic 



In conducting the pathological study of the kidneys from 

 these two types of animals every precaution was employed to 

 eliminate sources of error by using several fixing fluids for the 

 tissue from each experiment and by adhering to a uniform stain- 

 ing technique. 



Tissue was fixed in 10 per cent formaline, Zenker's fluid, and 

 in corrosive-acetic. The formaline and Zenker fixed tissue was 

 imbedded in cellodin, while the corrosive-acetic fixed tissue was 

 imbedded in parafiin. Cellodin sections were cut varying be- 

 tween 10 to 15 micra while the parafiin sections used for the 

 comparative study were 6 to 8 micra in thickness. The stains 

 employed were haematoxylin and erosin. In addition to this, 

 frozen sections were made and stained for fat by Herxheimer's 

 Scharlach R. method. As has been clearly shown by Bullard 

 (4) fat proplets in considerable number may be demonstrated by 

 this stain, when Herxheimer's modification is used, which would 

 be missed by the simple alcoholic solutions of Scharlach R. and 

 of Sudan. III. 



The following pathological report should be considered as a 

 summary of the essential differences in the kidneys of these two 

 two types of animals. A detailed discussion of the pathology 

 will be published elsewhere. 



In adult animals which had been rendered nephritic by uran- 



