50 JOFRNAL OF THE MiTCHELL SoCIETY [June 



proximal convoluted tubules, has become acutely swollen, with 

 a part or complete occlusion of the tubular lumen. The epi- 

 thelium is in various stages of degeneration and necrosis (fig. 

 3). The rapidit}'' with which this swelling develops is remark- 

 able. 



In the kidneys of the young animals following Grehant's anes- 

 thetic, the same type of changes are induced, but to a much less 

 extent. Thus there develops in the cortex a pale zone which is 

 much less extensive than in adult animals and microscopically 

 the fatty changes in this zone are found to be less pronounced. 

 Equally noticeable as the difference in the fat content (micro- 

 scopically demonstrable) is the difference in the degree of 

 involvement of the tubules of the labyrinth. In the young ani- 

 mals which have remained diuretic the severe grade of swelling 

 of the epithelium which was so noticeable in the adult animals 

 is comparatively slight or a])sent (fig. 4). 



The difference in the renal pathology of animals anuric and diu- 

 retic following morphine-ether 



With two exceptions these animals following morphine-ether 

 remained diuretic. 



The diuretic group was composed of both young and adult 

 animals. In this group uranium induced the same type of 

 changes as have been described in the animals which were given 

 Grehant's anesthetic. When, however, morphine-ether was em- 

 ployed as the anesthetic, the fatty changes which had been in- 

 duced by the uranium were not increased to a degree comparable 

 to the increase in these changes which followed Grehant's anes- 

 thetic, and also the acute swelling of the epithelium of the 

 tubules of the labvrinth was either absent or much less marked 

 (fig. 5). 



The exceptions to this statement are found in two animals 

 which were very old ; and these animals following morphine- 

 ether showed a pathological response on the part of the kidney 

 which was comparable to the pathology seen in the kidneys of 

 the adult animals which received Grehant's anesthetic, and like 

 these animals they were rendered anuric. 



