52 Journal of the Mitchell Society- [/wne 



the relative oxidative capacity of young and adult animals is 

 not especially visionary. 



In addition to the evidence of a disturbed metabolism that 

 is manifested by the appearance of glucose in the urine, the 

 use of uranium also induces fatty changes in the kidney and 

 in the liver. So far as their severity is concerned these 

 changes bear the same relation to the age of the animal as 

 was seen to exist for the percentage of glucose in the urine. 

 The fatty changes in the liver and in the kidney are much 

 more pronounced in the adult animals than the}^ are in the 

 young animals. 



When these nephritic and glycosuric animals are given an 

 anesthetic, those changes, of whatever origin they may be, 

 which have been induced by the uranium injections become 

 greatly augmented. The percentage of glucose in the urine is 

 increased, the fatty changes in the kidney and in the liver are 

 more marked, and the nephritis is so increased in severity that 

 certain of the animals rapidly develop an anuria. 



These changes which are induced by the anesthetic are also 

 influenced by the age of the animal, and they are found to be 

 more pronounced in the adult animals than they are in the 

 young animals. An observation similar to this has been made 

 by Whipple (6), who was able to show that chloroform in- 

 duced but slight fatty degeneration and liver necrosis in young 

 pups, while in adults a marked central hyaline necrosis of 

 the liver was induced. 



Not only does the age of the animals influence the severity 

 of the action of the anesthetic, but the type of anesthetic em- 

 ployed also aids in determining the severity of its effect. 



Of the two anesthetics which were used in the experiments, 

 Grehant's anesthetic gave more evidence of being toxic and 

 had more effect in increasing the severity of the nephritis 

 and in establishing a condition of anuria. 



The active anesthetic ingredients in Grehant's anesthetic 

 are chloroform and alcohol, and from the observation which 

 has just been made, it would appear that of the two anes- 

 thetics, Grehant's and morphine-ether, Grehant's which con- 



