lOlJf] Action of Various Diuretics 55 



of the kidney, and which so alter the composition of the blood 

 as to favor diuresis. 



The investigation would, therefore, tend to favor the con- 

 ception of the kidney's activity being more dependent upon 

 the secretory capacity of its cells than upon any mechanical 

 conception of the action of the vascular mechanism of the 

 kidney. 



CONCLUSIONS 



1. In dogs in which an acute nephritis has resulted from 

 the subcutaneous administration of uranium nitrate in the 

 dose of 6.7 mgs. per kilogram the severity of the nepritis, of the 

 glycosuria, and of the polyuria is influenced by the age of the 

 animal. The changes in the kidney and in the urine are more 

 marked in adult animals than they are in young animals and in 

 puppies. 



2. When such nephritic, giycosuric, and polyuric animals are 

 anesthetized by Grehant's anesthetic or by morphine-ether, the 

 severity of the nephritis is increased, and the output and compo- 

 sition of the urine is changed. 



3. The increase in the severity of the nephritis is more 

 marked from the use of Grehant's anesthetic, the active anes- 

 thetic ingredients of which are chloroform and alcohol, than 

 from morphine-ether. 



4. In addition to the fact that the type of anesthetic influ- 

 ences the renal pathology the age of the animal also aids in 

 determining the severity of the changes. The changes are more 

 pronouncel in adult and old animals than in young animals and 

 puppies. 



5. Following the anesthetic these nephritic animals either be- 

 come anuric or remain diuretic. 



6. In the anuric group, which is principally represented by 

 the adult animals which have received Grehant's anesthetic, the 

 condition of anuria is influenced by various diuretics. 



7. The failure of this group to respond to diuretics is more 

 likely due to the destruction of the epithelium of the kidney 

 than to any physiological or anatomical change in the vascular 

 element of the kidney. 



