56 Journal of the Mitchell Society [June 



8. Those animals that following the anesthetic are not ren- 

 dered aniiric are responsive to the same diuretic substances 

 which in the anuric group have been shovni to have no diuretic 

 value. 



9. In this diuretic group of animals, regardless of whether the 

 anesthesia has been induced by Grehant's anesthetic or by mor- 

 phine-ether, the epithelial involvement of the kidney is much 

 less severe than in the anuric group. 



In conclusion I desire to acknowledge my indebtedness to Dr. 

 J. P. Jones for his valuable aid in conducting the experiments. . 

 Chapel Hat, N. C. 



BIBLIOGRAPHY 



(1) MacNider : Jour, of Pharm. and Exper. Ther., iii, 4, March, 1912. 



(2) Benedict: Journ. of Amer. Med. Assoc, Ivii, 15, October 7, 1911. 



(3) MacNider: Proc. Soc. Exp. Biol, and Med., x, 3, 1913. 



(4) Bullard: Journ. of Med. Research, xxvii, 1, 1912. 



(5) Chittenden and Hutchinson: Trans. Conn. Acad, of Arts and Sci., 

 vii, p. 261. 



(6) Whipple : Journ. of Exper. Med., xv, 3, 1912. 



(7) Pearce, Hill and Eisenbrey: Journ. of Exper. Med., xii, 2, 1910. 



EXPLANATION OF PLATE 



1. Kidney of an adult animal, nephritic, glycosuric and polyuric from 

 uranium. The epithelium is shrunken and gives to the lumen of the tu- 

 bules undue prominence. The epithelium shows an early vacuolation. 

 The glomerular vessels fill the capsular space. The tubules contain granu- 

 lar detritus. 



2. Kidney of a puppy, nephritic, glycosuric and polyuric from uranium. 

 The changes in general are similar to those seen in figure 1. 



3. Kidney of an adult animal following Grehant's anesthetic given in 60 

 per cent strength. Prior to the anesthetic the animal was excessively poly- 

 uric. Following the anesthetic, within forty minutes, the animal became 

 completely anuric. The figure shows the acute swelling of the epithelium 

 with an occlusion of the lumen of the tubules. The epithelium of the be- 

 ginning of the collecting tubules is spared. These tubules remain open. 

 The glomerular vessels do not fill the capsular space. This figure should 

 be compared with figs. 1 and 4. 



4. Kidney of a puppy following Grehant's anesthetic. The animal had 

 been rendered nephrhic with the same quantity of uranium per kilogram 

 as had been used for the adult animal, figure 3. The puppy was anes- 

 thetized with the same quantity of Grehant's anesthetic per kilogram as 

 was the adult animal. The figure shows the absence of epithelial involve- 



