50 



ANIMAL I'ltYrANOSOMlASI^S IN Till': AN(i I.O-KC Yl'Tl AN SCDAN 



I )rii|;-ri,'actiDns 

 ill gerbils 



Morphology 



•j. Hraclii',1 In drKijs. Sumo uxpuiiiiioiits have been caiiiu<l out with disuaso 

 l)roiliicod in gerbils by this tiypanosoine. This animal has been selected as the course 

 of the disease is an acute one, the tiypanosoine being constantly in tlic blood till death, 

 and the fallacies due to dealing with a chronic disease in which the tiypaiiosomes appear 

 and disappear of their own accord, are avoided. One dose of metallic antimony in 

 sterile olive oil (3 to 5 minims) causes complete clearance from the blood of all 

 trypanosomes in from 2-3 hours. Kocurrcncc takes place after several days Init tlie 

 iuitimony acts with great trypanocidal vigour. 



One dose of Ehrlich's "(iOG" given in the same way causes a dimiiiutiun in the 

 number of trypanosoines in 24 and 48 hours and probably does not postpone the end 

 for more than 2 or 3 days— it is relatively weakly trypanocidal. The exact amount 

 of antimony and " C06 " in the dose is not here specified as it has been found by the 

 writer from experiments performed both hero and in London that probably (jidy a small 

 l)roportion of the drugs thus injected is actually absorbed Ijy the body and thus rendered 

 available for trypanocidal effects. 



I do not propose to outer into a discussion as to whether Mr. Buchanan's work on 

 tlie developmental and intra-corpuscular forms as found by liim will necessitate a change 

 of nomenclature in this type or not. His work on this point is very interesting and will 

 be found in an article by itself following this paper. At present, however, I may say 

 tliat I do not thiidv we have sufficient grounds for eml«uking on fresh nomenclatures. 



Type 2 

 2'. evansi (Plate I., fig. 3) 



The laboratory strains here of tliis tiyi)aiu>sonio have been obtained fiom camels 

 but there are some grounds for believing that mules and horses are at times alToetod. 

 The disease is, as far as can be ascertained, probably widely distributed in the Sudan 

 desert country w-here the camel is used. Its recognition by us as affecting camels in 

 such widely separated districts as Kordofan and the Red Sea Province gives colour 

 to this supposition. 



(n) Living and unstained. \n actively motile ti-ypanosomo of a strikingly inononiorphic 

 type, no markedly noticeable variations in length occurring in the unstained parasite, 

 an observation which is continued by measurements and study of the stained specimens. 



(6) Fixed and stained. It is characteristically a long slender trypanosome with a 



well-developed tlagellum, and tiie posterior end is definitely seen to be what is called 



" pike-hoaded." It certainly closely resembles the classical picture of tiie Trypanosome 



of fiidiiin Surra. 



MKASUBEMENTS OP TYPE 2 (T. evami) 



( OU- 



