SPIEOCH^TOSIS OF SUDANESE FOWLS 83 



One need not here take up the question of the use of therapeutic agents as a means of Action of 

 settling the above question. The matter will be found discussed under the eighth heading, 

 and it need be merely said that the use of " 606 " by subcutaneous injection in appropriate 

 doses rapidly drove all spirochsetes out of the peripheral blood and appeared also to 

 induce changes in the bodies which led to their eventual disappearance, while, as already 

 mentioned, some highly suggestive results were obtained {vide jMijes 101 and 102). 



If we search for analogies which may throw light on the subject we find the 

 observations of Galli-Valerio and of Bouet, already quoted, to be at least significant, 

 although neither of these authors is so far prepared to subscribe unreservedly to Sambon's 

 hypothesis or apparently to accept such arguments as one has hitherto adduced. The 

 same may be said of the findings and conclusions of Dschunkowsky and Luhs, though here 

 we are not on such certain ground. For one thing I have only seen extracts of their 

 papers. For another, they seem to be describing several curious appearances in the blood, 

 possibly no one of which is identical with what I have called, possibly erroneously, as will 

 be seen, the " after phase." 



It must be remembered also that neither Blaizot nor Dodd were able to find the 

 inclusions, although it is true that they may have been working with a different strain of 

 spirochiEte. This is very probably the case so far as the Australian observations go, but 

 the Tunisian strain certainly resembles that with which one has been working in several 

 important particulars. Jowett's recent discoveries in South Africa are naturally of special 

 interest, and his future work may serve to throw confirmatory light on tlie problem. (See 

 also references to recent papers by Bosanquet and Dobell, jjaye 107.) 



Another point of interest was kindly brought to my notice by Colonel Sir \V. B. Leishman, 

 F.R.S. He told me that he attended a meeting of the Pathological Society of Great Britain 

 and Ireland, where a paper was read by Dr. Henry, on the heemoprotozoa of British sea-fish. 

 A spirochietosis was described, and at the accompanying lantern demonstration Sir W. B. 

 Leishman noticed inclusions in the red cells of the tish which showed the spirochujtes in 

 its blood. He told me these forms closely resembled the bodies of fowl spirochsetosis. 

 A portion of Henry's^ paper has since appeared, but it is only a preliminary note, and 

 though a Sp. yadi pollachii has been described as a new species no mention is made of red 

 cell inclusions. A more detailed paper is promised shortly. 



One also finds an account by Tidswell- of " rounded bodies," possibly protozoal, in the Possible 

 blood corpuscles of a leather-jacket fish {Monacaiithuf sp.). The description given certainly ^/"M^f*^^ '" _.. 

 suggests my " after phase " bodies, but in no instance were more than two found in one 

 red cell. The nature of these bodies is regarded as uncertain. They do not suggest the 

 product of degenerative processes, and the final conclusion reached is that " if they are not 

 protozoal they are more or less normal products of the cell, either when in its younger 

 condition or adult form." They ask if they may be ceutrosomes like those described by 

 Ross, Moore and Walker in the erythrocyte of the axolotl, the crocodile, man, etc., but find 

 that they are quite unlike these. No statement is made as to whether spirochaetes were 

 found in the tish. I should not be surj)rised to find that tish of this Australian species 

 suffer from spirochtetosis. 



I mentioned the so-called cytamoebae of frogs and other reptiles, in the paper on fowl 

 spirochtetosis in our Third Report. It is possible that Carini's^ work on trypanosomes 



> Heury, Herbert (1910), "On the Haemoprotozoa of British Sea-Fish (A Prelimiuary Note)." Journal of 

 Pallwlogij and, Bactcrioluijy, Vol. XIV., p. 463. 



- Tidswell, P. (1909), l!rp,„-U of tlw Goixniinciit Biii-om of Mkrohioloyij. New South Wales, p. 45. 



' Cariiii, A. (February 25, 1910), "Stades Endoglobulaires des Trypanosomes." Ann. dc I'Inst. Past. 



