264 Aiumal Report for VM\ of Royal Veterinary College. 



It ought to be stated that the final rapid progress of the 

 disease took place in spite of a second course of treatment with 

 the iron and acid mixture, which was begun on May 28, soon 

 after it was observed that the animal was again scouring. 



In view of the apparent success of the treatment to which 

 the above described cow was submitted, it was resolved to try 

 the effect of sulphate of iron, with or without the acid, on a 

 number of other advanced cases of Johne's disease. In some 

 of these the treatment failed entirely, but as a rule it seemed 

 to have a beneficial result, although hardly in any case was 

 the improvement so sudden and marked as in the case already 

 described. By way of illustrating the various effects of the 

 treatment, the condensed history of three other cases may 

 be given. 



Case II. — This was a cross-bred cow of rather a bad type, 

 aged about six years. She was admitted on December 5, 1913. 

 There was marked diarrhoea and the animal was in rather poor 

 condition. The diagnosis was confirmed as in the previous 

 case. Her weight on December 20 was 53 st. 2 lb., and 

 treatment with sulphate of iron was begun on that date. 



During the following fortnight the cow became very weak 

 and emaciated, and the appetite was bad. During the third 

 week of January there was a slight improvement in the 

 character of the ffeces, but after that diarrhoea set in again, and 

 it was thought advisable to stop the administration of the 

 sulphate of iron on January 26. 



On the following day treatment was commenced with 

 powders containing catechu and chalk. Her weight on 

 January 30 had fallen to 41 st. 8 lb. During February 

 improvement set in, although the diarrhoea still continued ; and 

 on the 25th treatment was begun with the iron and acid 

 mixture, alternated with astringent powders. On March 4 

 the iron and acid mixture was replaced by sulphate of 

 iron alone. There was more or less diarrhoea until towards the 

 end of April, when the faeces became quite normal. The 

 following figures afford the best indication as to the animal's 

 improvement between February and June : — 



February 28 . 

 March 13 . 

 March 28 . 

 April 11 

 April 25 

 May 9 . 

 May 23 

 June 6 . . 



In the month of June the animal had a serious relapse. 

 The diarrhoea returned, and the weight fell nearly 7 stones in 



