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value of my inoculations when not followed by a mild attack of the disease, 

 and it is rather upon the circumstances attending my six successful inoc- 

 ulations that I rely in order to prove the aptitude of the C. mosquito for 

 transmitting yellow fever. If this be once admitted, it must follow that 

 the disease is actually so transmitted, since it must constantly happen, in 

 a place like Havana, that unacclimated subjects are stung by mosquitoes 

 which have previously bitten yellow fever patients. 



My first inoculations by means of mosquitoes were performed under 

 the follolwing circumstances : A group of twenty unacclimated soldiers, 

 who were quartered on the heights of the Cabanas, on the other side of 

 the bay, were picked out for my observation, and were only allowed to 

 cross the bay in batches of four or five on the days they were sent to my 

 office, where I tried their blood for hematimetric purposes. Five of the 

 group were inoculated by me at different dates between the 29th of June 

 and the end of August, 1881. The first three were followed, at the end of 

 five or fourteen day's incubation by an attack of fever of several day's 

 duration, diagnosticated by the attending physicians at the military 

 hospital as "regular yellow fever" in the first case, and "abortive yellow 

 fever" in the two others. The fourth inoculated soldier suffered only from 

 continued headache, and on the fifteenth day after the inoculation, came 

 to my office with slight fever (temperature 100. 7° F., pulse 100), but 

 was not laid up. The fifth did not return to my office. I was informed 

 that he had felt poorly a few days after the inoculation, but was not laid 

 up. I have been able to trace the history of these five cases until the 

 beginning of last year. None of them had been reported, up to that date, as 

 subsequently attacked with yellow fever. Of the remaining fifteen soldiers 

 of the group, upon whom the inoculation was not performed, none were 

 attacked with yellow fever during the period of my observation, June 2S 

 to September, 1881. 



CASE 1.— On the 30th of June, 1881. one of the soldiers of the above 

 group (F. B.), twenty-two years of age, three months in Havana, having 

 had previosly some attacks of intermittent fever, was inoculated by means 

 of a mosquito which had bitten, two days before (June 28th), a patient in 

 the fourth day of yellow fever and who died thirty-six hours later. 



July 14. The inoculated soldier w T as taken sick and went to the 

 Military Hospital, where I was only able to see him on the 16th (third 

 day of his illness). 1 found him with slight fever, slight yellowish tinge of 

 conjunctivae, pains of invasion almost disappeared the urine gave distinct 

 evidence of albumen with heat and with nitric acid, not having presented 

 any in the morning. The clinical report of the attending physician, together 

 with my own observation, gave the following result. 



1st. day. July 14. Invasion preceded by a few days of discomfort. 



2d day. Morning: Temp. 101.8° F. ; pulse 92; resp. 28; face and eyes 



