167 



5th day. Morning : Temp. 100.4° F. ; pulse 68 ; no ahumen ; 

 conjunctivae yellowish; gums de not bleed on pressure. 



6th day. Morning: Temp. 101.4° F. ; pulse 72. Midday: Temp. 103.1° 

 F.; pulse 72. Evening: Temp. 103.2° F. ; pulse 70. 



7th day. Morning: Temp. 98° F. ; pulse 54; yellowish tinge on the 

 forehead; no pains; has perspired freely in the night; milk allowed. 

 Evening: Temp. 98.6° F. ; pulse 52; apetite returning; rapid convalescence. 



The general type of the fever, with remission on the fourth day, and 

 defervescence on the seventh, bears a strong resemblance to some forms 

 of natural yellow fever that I have observed. The patient has since 

 remained protected. 



The following case is remai'kable from the circumstance that most of the 

 conditions were fulfilled that can well be secured in the vicinity of Havana, 

 in order to avoid the chances of independent infection from other sources 

 besides the inoculation. The place selected for the experiment was the same 

 country residence or "Quinta" rented by the Jesuit Fathers since 1872, 

 near the "Quemados de Marianao", to which Dr. Stanford E. Chaillé has 

 alluded in his remarkable report as President of the Yellow Fever 

 Commission which visited Havana in 1879 (Annual Report of the National 

 Board of Health, Washington, 1880, p. 276). In the course of eleven years 

 (1872-1883), the only case of yellow fever which developed among the many 

 liable subjects who have spent their summer vacations at this place, during 

 their stay, occurred in 1880 in a young priest who had been going backwards 

 and forwards to Havana during the previous fortnight, and who was 

 attacked with the disease during the last visit to the city, where he remained 

 and died. It is more than likely that he had contracted the infection in 

 town, and not at the Quinta. 



Toward the end of June, 1883, several young priests and a servant, all 

 unacelimated and having arrived from Spain the previous autumn, 

 happened to be staying at this country-place, and I availed myself of their 

 willingness to submit to my inoculation experiments. 



CASE V. — P. U., one of the unacelimated priests, a young man of 

 spare habit, having gone to the "Quinta" toward the end of June, 1883, 

 did not again visit the city nor the neighboring town of Marianao until 

 the following September. On the 15th of Jidy a first unsuccessful attempt 

 was made with a mosquito contaminated from a case in the seventh day of 

 yellow fever; a full month was then allowed to elapse before a second 

 attempt on the same person. 



August 18, 1883, P. U. was inoculated with a mosquito which had 

 bitten on the 13th and 16th two separate cases of yellow fever, each in 

 the sixth day of their illness. 



On the 26th of August, eight days after inoculation, P. U. was taken 

 ill about 8 a. m. with headache, pains in the loins, and fever (temp. 100.7° 



