232 



Among 36— regarding which no record has been kept of the particular 

 species of mosquito that was used, five were followed by- 

 pathogenic resuljts, i. e., 14%. 

 21 — who were inoculated by the small mosquito, seven were fol- 

 lowed by pathogenic results, i. e. 27%. 

 „ 17 — inoculated with the medium sized mosquito, only two were 

 followed by pathogenic results, i. e. 12%. 

 15 — inoculated with large C. mosquito, three were followed by 

 pathogenic effects, i. e. 20%. 



None of the seventeen inoculated persons who had presented pathogenic 

 effects within the 25 days following their inoculation have been subse- 

 quently attacked with albuminuric Yellow Fever, and only one of them 

 experienced a second attack of non-albuminuric fever, when afterwards ex- 

 posed to a severe infection. 



Among the total of ninety inoculated subjects, only three fatal cases 

 of Yellow Fever and 8 of regular or severe albuminuric fever subsequently 

 occurred having presented no pathogenic effects at the time of the inocu- 

 lation. 



I do not believe that any other protective measure has so far given 

 results so favorable as those obtained by my mosquito inoculations and, 

 from recent experience, further improvement may be expected when the 

 small C. mosquito shall be exclusively used. It cannot be denied, however, 

 that the mosquito inoculation is troublesome and requires so much care in 

 its details that it is not likely to gain adherents. Let us hope, therefore, that 

 the true germ of the disease will soon be proven, in order that a readier 

 method of vaccination may be instituted. In the meantime, I have per- 

 formed some other inoculations with blister serum collected from healthy 

 subjects, who had experienced recently an attack of Yellow Fever. They 

 have never occasioned any inconvenience, but a longer observation is neces- 

 sary before anything can be said about their efficacy. 



The special measures which might be adopted against the propagation 

 of Yellow Fever through mosquitoes must be left to the criterion of those 

 who accept my theory; but the principal indications must be: (1) to prevent 

 those inseccts from stinging Yellow Fever patients, (2) to destroy as far as 

 possible the moquitees which may have become infected (bearing in mind 

 that in a closed space, a temperature of 50° C. is suficient for that purpose ; 

 and (3) finally, to consider any place unsafe so long as the last mosquitoes 

 which have stung Yellow Fever patients may be alive in it, from 35 to 40 

 days being reckoned as the term of their existence under the most favorable 

 circumstances. 



