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some thermic reaction, but the subsequent symptoms were not characteristic, 

 and they all recovered. The result was different, however, with the young 

 rabbits, weighing less than 1000 grammes, which I inoculated on March 

 11 and 23 with the same culture. The first rabbit, a male (like all the 

 others), weighed 810 grammes, and had been brought from the country 

 two days before. I injected into its peritoneal cavity 5 c. c. of the filtered 

 culture, and another 5 c. c. under the skin of the abdomen. The second 

 day its temperature had risen to 40° 6 C. ; the third to 40° ; the fourth to 

 39° 8; the fifth it fell to 38° 8; on the sixth a second paroxysm set in 

 with 11°; the seventh day the temperature oscillated between 40° 7 and 

 41° 1; on the eighth between 40° 3 and 40° 7 ; on the ninth day there was 

 a defervescence to 38° 3, the rabbit dying 814 days after the inoculation, 

 with a loss of a fourth of its weight. A superficial autopsy showed intense 

 venous congestion, the right heart being distended with blood, injection of 

 the mesenteric and peritoneal vessels, congestion of the liver and kidneys; 

 the bladder contained a fair amount of urine, with a trace of albumen. At 

 the site of the inoculation there was neither redness, nor suppuration, nor 

 oedema. Hardened in alcohol, sections of the liver and kidneys showed small 

 hemorrhagic infarcti, small punctuate haemorrhages being visible in the 

 regions of the glomeruli, and streaks of blood in the pelvis of the kidneys. 

 No cultures were made. 



The second rabbit weighed 1000 grammes before inoculation on 

 March 23. I injected 10 c. c. of the filtered culture into the peritoneal 

 cavity, and 9 c. c. under the skin. The temperature was not taken during 

 the first eighteen hours. On the second day it oscillated between 39° and 

 39° 4; the third between 38° 5, and 39° 4; the fourth between 38° 5 and 

 39° 7; the fifth it kept at 38° 6; sixth, in the morning it fell to 38° 2, the 

 second paroxysm setting in the afternoon 39° 8; the seventh day the 

 temperature ranged from 38° 6 to 39° 6; the eighth between 38° 8 and 

 39° 6; the ninth it was at 39° 6 in the morning but fell to 38° in the 

 afternoon, the animal dying at 8 a. m. the following day — 8% days after 

 the inoculation. The autopsy gave the same findings as in the first rabbit, 

 with less venous stasis and no albumen in the urine. No cultures were 

 made. 



On March 27 Dr. Davalos planted a second balon of peptonized broth 

 with colonies of the yellow tetracoccus which had served to verify the 

 purity of the previous culture. At the end of eighteen days we passed the 

 contents through the Kitasato filter, with the same result as before; for 

 we were able to ascertain, a few days later, that some live germs had 

 passed through the filter. On the 15th of April I inoculated two adult 

 rabbits; one weighed 1385 and the other 1530 grammes. The first received 

 20 c. c. of filtered culture in the peritoneal cavity, the other had the same 

 amount injected under its skin. The acute intoxication observed in the 

 young rabbits did not occur, but in its place a state of chronic marasmus 



