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During the seizure the lips are cyanotic, the pupils dilated, and there occur 

 certain movements of the head and neck which remind one of hiccough or 

 the effort of swallowing, and once I have seen the animal extend its neck, 

 opening and shutting its mouth three or four times, as if attempting to 

 bite. After the first attacks the rabbit rises on its legs, and at times, during 

 a pretty long interval, it appars to have completely recovered, being anxious 

 to eat, and moving about as if nothing had occurred. Later, the seizures 

 are repeated at shorter intervals, till, finally, a state of stupor or coma sets 

 in, in which one only perceives that the animal is not dead by the 

 persistence of respiration. This finally ceases, and death takes place, with 

 the head thrown back and the legs streched out drawn close to the body. 

 In one of the rabbits there had been dyspnoea before and during the 

 attack, and the autopsy showed markedly congested lungs, but no 

 hepatization. 



In describing at such length the death of these rabbits inoculated 

 with the tetracoccus, my object has been to place beyond a doubt the 

 eclamptic nature of their last symptoms. The intimate relation between 

 eclampsia and uraemia, on the one hand, and the fact that in the great 

 majority of fatal yellow fever cases the immediate cause of death is 

 attributed to uraemia, will explain my dwelling so much on this point. The 

 examination of the cranial and medullary cavities would have been of 

 interest, as well as the histological analysis of the extirpated viscera, but 

 I had no time to make these investigations. 



Tetraccocus from Yellow Fever Patients 



Iu the month of June I determined to obtain the tetracoccus directly 

 from yellow fever patients, in order to compare its pathogenic effects with 

 those of the same micro-organism obtained by means of the mosquito. On 

 June 27 I planted two tubes of glycerine broth with the finger blood of a 

 patient in the fourth day of melano-albuminuric yellow fever, who 

 occupied bed N.° 20y 2 of Dr. Scull's ward in the Mercedes Hospital. Both 

 tubes gave pure cultures of the yellow tetracoccus. An inoculation with 

 16 c. c. of a six days' culture proceeding from pure colonies of this sample 

 into rabbit M, produced a rise of temperature of 40° 7 within nine hours, 

 followed by a two days' incubation; the regular febrile attack declaring 

 itself on the fifth day after the inoculation. This fever showed a remission 

 on the fourth day, and the animal died on the seventh or eighth (eleventh 

 since the inoculation), with dyspnoea, eclampsia, and coma. The autopsy 

 showed haemorrhages over the heart and over the surface of the great vessels 

 at their origin ; haemorrahagic inf arcti in the tissues of the liver, kidneys, 

 and lungs ; hyperaemic and punctate haemorrahages upon the gastric mucous 

 membrane; venous stasis; and the urine drawn from the bladder was free 



