316 



after inoculation; while R presented a remission on the third day, and 

 died in the second paroxysm of this fever seventy two hours after ino- 

 culation. Both these rabbits presented before death the eclamptic symtoms 

 described above. The autopsy showed hemorrhagic infarciti in the liver, 

 kidneys, and lungs ; there was a trace of albumen in the urine of Q, but none 

 in that of R. Cultures from heart blood gave the pure straw-coloured 

 tetracoceus. 



The facts developed in the present series show the pathogenicity of 

 the yellow fever tetracoceus, and its similarity or identity in kind with 

 that of the mosquito tetracoceus ; attention being at the same time called to 

 the circumstance that the various intensities observed in its virulence were 

 in keeping with the severity of the disease in the patients from whose 

 blood or milk the germs had been obtained. 



Spontaneous Transmission of Tetracoceus Infection 



The greater part of my inoculated rabbits of the mosquito series aud 

 some of the blood tetracoceus series were kept at the Laboratory of the 

 Crónica Médico-Quirúrgica ; the r< mainder were kept at my house, in order 

 to exclude any influence of locality. This circumstance enabled me to 

 witness an example of contagion in a rabbit of a foreign race, with a thin 

 skin and long grey hair. It was a male, and weighed 650 grammes on being 

 brought from the country on March 22, at which time other rabbits were 

 being observed. The grey one appeared healthy, and received no inoculation, 

 but was left in the same portion of the stable together with the inoculated 

 rabbits. At the end of eight days it was found dead, with its head thrown 

 back, as in the case of rabbits which had died from the inoculation; and 

 cultures from its heart blood developed pure cultures of yellow tetra- 

 coceus. 



On June 26 eleven days had passed without there being any rabbits 

 at my house. A Spanish wet nurse (B. V.) came with one of my relations 

 to spend some time there. She had suffered no febrile disturbance since 

 her arrival in Cuba (November 1894), not even during her confinement, 

 which took place in April of this year. On June 29 she awoke with fever 

 and symptoms of a probable attack of yellow fever, and was transferred to 

 a large well-ventilated room in Acosta Street, where 1 attended her during 

 her illness. Hers was a typical case of non-albuminuric yellow fever, if we 

 except a slight opalescence in a single specimen of her urine of the third 

 day, on testing it with Esbach's solution, and boiling. The acme of the 

 fever during the first paroxysm was 39° 5; there was a remission to 37° 8 

 and 37° 1 between the fourth and fifth days, a second paroxysm, with 

 38° 8 and 39° 2, on the fifth and sixth, and defervescence to 36° 5 on the 

 seventh. No quinine nor other antipyretics had been used. The urine was 

 scanty ; the gums bled a little, and some bloody phlegm was spat up between 

 the fourth and sixth days. On the third day I planted two tubes of broth 



