which belongs lo (¡rassi and Uoss. Dr. Manson was ■ of the genial 



masters in the new doctrine, and with him Btands Dr. Pinlay. The whole 

 superstructure rests upon the observations of these two men. M is interest- 

 ing to note thai both worked alone and removed Er the greal scientific 



centres, and thai their work was ignored for a time. Their doctrine of the 

 transmission of disease in man by the sting of insects has been completed 

 by Mich able experimenters .-is Qrassi, Uoss, Kock, Dow. Reed, Lazear, 

 ( larroll, Agramonte and others. 



There is qo fundamental fact, nor any important practical application 

 of the mosquito doctrine in connection with yellow fever, thai has not been 



clearly foreseen and slated h\ \h\ Pinlay, The principles and the methods 



of experimentation were pointed out by him ; and when the time arrived for 

 the most receñí experiments, on the basis of the late discoveries in malaria, 

 the investigators had to apply to him for information concerning the in- 

 sects that he. with singular discernment, had pointed out as the carrier of 



the disease, and they had to commence their investigations with specimens 



of the culex mosquito (stegomyia fasciata) furnished by himself. 



W'e believe, therefore, that the publication of the following inedited 



manuscript will he received with interest, ami that we may he allowed to 

 prefix a. brief history of the doc cut . 



It was written by Dr. Pinlay in December of 1891, and was forwarded 

 for publication in the American Journal of ih< Medical s<i<nt<s, of which 

 \h-. 10. I'. Davis was the Editor. The paper was accepted, hut its publica- 

 tions being delayed, it was reclaimed by Dr. Pinlay because it was losing 



its opportuneness as an answer to criticisms made by Dr. Sternberg in a 

 previous issue of the same Journal. Dr. Davis returned the manuscript 

 with a letter id' transmittal. 



When the Yellow Fever Commission "I tin United States Army (Drs. 

 Reed, La/ear. Carroll and Agramonte) published their announcement, and 



demonstration of Hit fact, that the hite of a mosquito 12 days infected 

 from a yellow lexer case would produce the disease. Dr. Pinlay declared that 

 his inoculations with insects only 2 or ■! days infected from a previous case 

 were intended to produce a minimal infection, hut that hi' had reason to 



believe that a Longer period of delay would increase the virulence. His 



first contention, namely, the minimal and protective infection has not thus 

 far been proven, and there are reasons to believe that it is not well founded ; 

 hut his second contention, that is, the positive infection by an insect more 



than ten days removed from the infecting case, has been confirmed beyond 

 all doubt, thus giving him. \h\ Finlay, the full righl in his fundamental 

 conception thai yellow fever is transmitted by the hite of the stegomyia 



fasciata. 



The paper will appear soincwat obscure in so points referring to 



the controversy with Dr. Sternberg, and \>r. Pinlay himself, in a letter to 



the writer, expresses his regrets that he cannot rewrite the paper and 



