454 



I linil it stated thai the mosquitoes during the epidemic presented a 

 different appearance from those previously noticed. 



In Dr. Sternberg's article in Wood's Reference Handbook, the 

 following conditions are given as those upon which depends the 

 development of yellow fever in places removed from its endemic foci: 



A. The introduction of the specific cause of yellow fever by yellow 



fever patients or through infected articles l'omites. 



B. Local conditions which favor the multiplication of the specific 

 germ external to the body. 



C. Favorable meteorological conditions. 



D. The presence of .susceptible persons. 



Retaining this very acceptable arragement 1 would, according to my 

 theory, modify Dr. Sternberg's statement thus: 



A. Introduction of the specific cause by yellow fever patients or 

 through contaminated mosquitoes. 



B. Altitudinal and meteorological conditions winch favor tin; 

 multiplication of the specific germ external to the body and the functional 

 activity of the C. Mosquito. 



C. The presence of susceptible persons. 



Among the experimental data intended to prove that contaminated 

 mosquitoes are capable of transmitting the disease. I need only recall the 

 cases reported in my article of 1886. In case N.° 1, a distinct attack of 

 albuminuric yellow fever oceured 14 days after the application of a 

 contaminated mosquito, the only one among twenty unacclimated soldiers 

 under my observation, who was so attacked, none of the others having at 

 that time received the mosquito inoculation. 



In case N.° 5, an unacclimated person while residing in a country 

 place from which he had not absented himself since over two months, and 

 in which no case of yellow fever had occurred for at least seven years, 

 was inoculated with a contaminated mosquito on the 18th of August 188:5, 

 eight days later, on the 26th, he was attacked with yellow fever of a mild 

 type, with trace of albumen on the fifth day. This person resided three 

 consecutive years in the City of Havana, after this attack, was absent two 

 years in Spain and now has again been two years in this city without 

 having experienced here any fever of any kind. 



Dr. Sternberg's demand that pathogenic effects should be constantly 

 obtained could only he to some extent admitted, provided the inoculations 

 Were performed with a number of contaminated mosquitoes that would 

 lie likely to develop a dangerous or fatal attack of the disease, an alterna- 

 tive which I would be unwilling to accept. 



My statistical results regarding the protection conferred by the 

 " Mosquito inoculation" against severe or fatal attacks of yellow lever, may 



