MALARIA AND ITS TRANSMISSION 15 



Spirito Hospital. The patient, a man who had been 

 an inmate of the hospital for six years, had never 

 had malaria. He was confined at night in a room in 

 which vessels containing mosquito larva? were placed, 

 and a new supply of these was placed in the room every 

 four to six days. The patient was severely bitten by 

 the mosquitoes which developed from the larvae. The 

 result was that the man acquired malaria, with sestivo- 

 autumnal parasites in the blood. The details of this 

 experiment were published by Bignami ; Grassi be- 

 lieved that infection was due to the agency of the first 

 species above named, as it was the most numerous. 

 A. claviger was only present in exceedingly small num- 

 bers, and perhaps none of this species bit the patient. 

 (It has since been proved that it could only have been 

 A. claviger that caused infection.)" 



The above description might lead one to believe that 

 the parasite of malaria is transmitted from the adult 

 mosquito to its larva, since the patient was bitten by 

 the mosquitoes developing from the larvae, but it does 

 not say that he was not bitten by the originally in- 

 fected mosquitoes. 



The following quotation from Manson l concludes 

 the experimental evidence. "Finally, on behalf of 

 the Colonial Office and the London School of Tropical 

 Medicine, with the assistance of Drs. Sambon and 

 Low, I instituted two experiments which dispose for 

 good and all of any objections that otherwise might 



1 Manson, Sir Patrick, 1909. "Tropical Diseases." 



