Fin 4. Diagram to show life history of parasite (Plasmodium vivax) of aestivo-autumnal malaria. 

 1-6 asexual or schizogonic cycle in human blood, requiring 48 hours to complete (72 hours in 

 quartan); 1 represents a malaria vermicule or sporozoite, either in salivary gland Of mosquito or 

 newly injected into human circulation; 2 represents a red blood corpuscle about to be parasitized by 



nuc 



rea< 



sporozoite; 3 shows a young parasite in signet ring form; 4, fully grown parasite with dividing 

 iclei; 5 shows parasite sporulated, but still iutracorpuscular; 6, sporulation, each body a merozoite 

 ady to enter a new corpuscle; some are sexual and may develop into gametes; 711 female gameto- 



cyte still intracorpuscular; 76, male gametocyte, also intracorpuscular; 8a, free female crescent, 

 which may sporulate, producing a parthenogenetic cycle (w, x, y, z); &b, male gametocyte or hyaline 

 crescent (crescents do not ordinarily appear in the blood until ten days or more after infection); 

 0-20 illustrates the sporogonic or sexual cycle of the parasite within the body of a female Anophebne 

 mosquito, requiring six to ten days and over to complete; ga, 06. female and male gametocytes in 

 stomach cavity of mosquito; 10a. female gamete (macrogamete) ; 106, exflagellated male gameto- 

 cyte; 11, deflagellated male gamete (microgamcte); 12, fertilization; (0 13 requires about 24 hours); 

 13, ookinete or to penetrate stoma< h ; 14, ookinete burrowing through stomach wall; 15, 



odkinete lying outside of stomach waU and inside peritoneal lining forming characteristic cysts, 

 growing progressively larger; (16-10) in which the parasite sporu ates, forming the sporozoites; 

 20 shows sporozoites (vermicule I e caping from cyst and migrating forward to sal, vary glands (21), 

 (14-20 requires 5 days or more) ; 21. salivary glands of female mosquito; 22 head of female Anoph- 

 eles. (Original, with suggestions from Grassi and Schaudin in Mense s Handbucti.) 



