Manchester Memoirs, Vol. Ivii. (191 3), No. 13. 7 



Only a small number of experiments were recorded 

 for the mice. It was found that they excreted besides 

 acetamide certain amines or ammoniated compounds, 

 which neutralised and fixed some of the carbon dioxide, 

 and thus showed by the baryta water test a smaller pro 

 portion of carbon dioxide than it should have done. 



The final results were obtained by putting the mouse 

 on the top of several layers of blotting paper, previously 

 saturated with a strong solution of citric acid, and dried, 

 which fixed the amines and ammoniacal compounds and 

 prevented them from interfering with the COo results. 



The figures obtained from the guinea pig experiments 

 are shewn in the tables and charts appended hereto. 



From the results given it will be seen that, on all 

 occasions where the barometer, hygrometer or thermometer 

 alters appreciably, there is a corresponding change in the 

 ])ercentage of CO.^ in the exhaled air of all, or nearly all, 

 the persons or animals tested. A rise in the barometer 

 producing a fall in the CO.,, and a fall in the barometer 

 producing a rise in the CO^, exhaled, and a marked 

 increase in humidity producing a fall, and a decrease 

 producing a rise in the COo exhaled. 



The rise of the temperature of the air produced a 

 lowering of the CO,^ in the exhaled air, and a fall in the 

 temperature produced a rise. The rate of the pulse seems 

 to have no influence on the percentage of CO.3 in the 

 exhaled air. 



The temperature (sub-lingual) of the body appeared 

 also to have little influence on the CO.2 in the expired air. 



I have pleasure in acknowledging the services of mv 

 assistant, Mr. Norman T. Fox, who has carried out these 

 series of experiments with great care and ability. 



