1902.] NATURAL SCIENCES OF PHILADELPHIA. 321 



according to Neumeister' s (27) scheme, the first bodies chemically 

 recognizable in the tryptic digestion of proteids are deutero-albu- 

 moses. Now, deutero-albmnoses, according to Fischer and this study, 

 behave as we have described under the general name album ose (see 

 p. 815). If granules appear before albumose is formed, therefore, 

 it is not probable that they represent food. May those in question, 

 however, not be albumose in a weaker solution, seeing that the 

 size of the granules depends upon the strength of the solution ? In 

 answer to this question two facts may be mentioned : (a) whereas 

 albumose granules take stains readily, these granules stain with 

 ditficulty; (b) where only a small number of albumose granules 

 are present they are usually very much larger than these (figs. 8 

 and 9, Plate XVI). If, then, any of the granules designated as 

 "small and poor-staining" (see Table I) are food, they must 

 represent a stage following albumose. Fischer has found the 

 true peptone (in Kiihne's sense) very difficult to precipitate, and 

 I have been unable to get any precipitate at all with killing 

 fluids from the filtrate after treating Griibler's preparations of albu- 

 moses with (^114)2804. If the true peptone were precipitated in the 

 cell, the granules would in all probability be very small, and Fischer 

 finds them also very difficult to stain (wenig tinctionsfiihig). Both 

 these properties are exhibited by the granules in question. It is 

 possible, therefore, that some of the small non-stained granules 

 occurring with the albumose, or after albumose may be expected to 

 have been formed, are true peptone. Granting this, however, we 

 should still have to account for a, the appearance of the granules 

 of this description in the starving cells, and b, the origin of many 

 granules found in the living cells and in the fixed material imme- 

 diately about the nucleus. The ferment hypothesis is still necessary 

 to account for both these facts. 



The attention of the reader will have been arrested by the densely 

 staining mass represented in figs. 6 (text) and 8, Plate XVI, lying 

 on the luminal side of the nucleus and extending toward the lumen. 

 It will be seen to cou.sist of densely staining strands (fig. 8), matted 



Hoppe-Seyler (35) found ihe action of the "liver" ferment of the cray- 

 fish Astacus fludiatilis to be pancreatic and not pei)tic, although the 

 reaction was sliglitly acid. Krukeiiburg (26) has sh»)wn the same to be 

 true also of several Brachyura. Fuially, the general adoption of the 

 name hepatopancreas for the digestive gland of the Arthropoda was in 

 recognition of the pancreatic nature of its secretion. 



