189 



NuTTALL (G. H. F.) & HiNDLE (E.). Experiments in the "Tryposa- 

 frol" Treatment of Trypanosomiasis (T. brucei) in Guineapigs and 

 of Piroplasmosis in Dogs.— Paras ilology, London, viii, no. 2, 

 September 1915, pp. 218-228. 

 In 1912, Brieger and Kraiise reported upon experiments with a dye 

 named tryposafroL which was stated to have cured nagana in rats 

 and guineapigs. Four laboratory strains of T. brucei were used in 

 the investigations. The animals were treated immediately after 

 inoculation or after the lapse of 1 or 2 days, the dye being given every 

 other day in quantities of 0*05 to O'l grm. mixed with the food. The 

 experiments have been repeated by other investigators, but always 

 with negative results. In the experiments carried out by the authors, 

 all guineapigs infected with T. hnicei (strain " ferox ") died whether 

 treated with tryposafrol or not. Both tryposafrol and novo-tryposafrol 

 exerted a directly injurious effect upon the guineapigs. The treated 

 guineapigs died from 5 to 33 days after inoculation, those untreated 

 from 23 to 45 days later. Of five dogs infected with Piroplasma canis 

 (Cambridge strain), 4 were treated and 1 not treated with novo- 

 tryposafrol. All the dogs died, although treatment was given under 

 the most favourable conditions, starting on the day of inoculation. 

 The drug exerted no influence upon the course of the disease, nor upon 

 the appearance of the parasites and their progressive increase in the 

 blood. Judging from the results on the dogs, novo-tryposafrol will 

 prove ecjually useless in the treatment of bovine piroplasmosis. 



Carter (H. R.). Memoranda from Malarial Surveys and Demonstra- 

 tion ^ov\ii.— Southern Med. Jl, Birmingham, Ala., viii, no. 9, 

 September 1915, pp. 750-753. 

 At Electric Mills, Miss., a sawmill village, the ground was impervious 

 to water and its surface was fiat. When one road to the sawmill 

 became full of holes and ruts it was abandoned and another made 

 close by. Breeding places for Anopheles were thus abundant. Filling 

 these with earth was unsatisfactory and expensive. Filling with 

 sawdust and bark trash was advised, and as these materials were 

 abundant, they were found much cheaper and also more effective for 

 the purpose. 



Brooke (G. E.). Contact Insecticides. — Lancet, London, clxxxix, 

 no. 4801, 4th September 1915, p. 571. 

 The following contact insecticide was devised by the author, Port 

 Health Officer at Singapore, and is strongly recommended ; the stock 

 solution forms an immediate, stable and non-inflammable emulsion on 

 the addition of water :— Stock solution : Carbon bisulphide 1, kero- 

 sene 20, mixed first by shaking ; then add Sanitas-Sypol 7, and keep 

 in a stoppered bottle. For use : Make a 10 per cent, solution in water, 

 adding the water to the stock and not the stock to the water. This 

 solution is a milk-white emulsion, practically permanent when corked, 

 but losing its insecticidal power with time, so that it should always 

 be prepared just before use. Using a sprayer giving a fine but strong 

 spray, bugs appear to be killed within a second or two. Two applica- 

 tions killed all the lice (over 2,000), and their eggs, on a young puppy. 



