42 F. C. STEWARD AND J. K. POLLARD 
development. In fact, some of the compounds in question may well function as in- 
hibitors or antimetabolites which arrest metabolic sequences that would otherwise 
occur. This possibility exists in a number of storage organs in which growth and 
protein synthesis are arrested so that soluble nitrogenous compounds may accumu- 
late. 
ACKNOWLEDGEMENTS 
In presenting this brief survey as the background for further discussion of free amino 
acids in plants, the authors speak for, and acknowledge their debt to, several colla- 
porators who have worked in the senior author’s laborato1y, but who may not all 
be mentioned by name. 
REFERENCES 
1U. Bacuracu, Biochem. J., 77 (1960) 417. 
2H. A. BARKER, R. D. Smytu, E. J. WawszxiEwics, M.N. LEE anp R.M. Witson, Arch. Bio- 
chem. Biophys., 78 (1958) 468. 
3H. L. Barratts, Ph. D. Thesis, Cornell University, Ithaca, N.Y., 1959. 
C. F. BAXTER AND E. Roserts, J. Biol. Chem., 233 (1958) 1135. 
5 L. BenortTon, M. Win11z, S. M. BIRNBAUM AND J. P. GREENSTEIN, J. dm. Chem. Soc., 79 (1957) 
6192. 
K. BIEMANN, G. G. J. DEFFNER AND F. C. STEWaRD, Nature, 191 (1961) 380. 
- 
a 
7 L. F. Burroucus, Nature, 179 (1957) 360. 
8 A.C. CHIBNALL, in Pyotein Metabolism in the Plant, Yale University Press, New Haven, 1939, 
Pp. 54- 
® A. R. CooKE, Arch. Biochem. Biophys., 55 (1955) 114. 
10 C. E. DENT, W. STEPKA AND F. C. STEWARD, Nature, 160 (1947) 682. 
11 L. FowpDEN, Nature, 176 (1955) 347- 
2 LL. Fowpen, Ann. Repts. on Progr. Chem. (Chem. Soc. London), 56 (1959) 359- 
13 L. FOWDEN AND F.C. STEWARD, Ann. Botany (Lendcn), 21 (1957) 53- 
M4 J. P. GREENSTEIN AND M. W1ni117z, in Chemistry of the Amino Acids, J. Wiley and Sons, New York, 
IQ6I, Pp. 25. 
Va 
. GROBBELAAR, Ph. D. Thesis, Cornell University, Ithaca, N.Y., 1955. 
16 N. GROBBELAAR, J. K. POLLARD AND F. C. STEWaRD, Nature, 175 (1955) 703- 
-17 N. GROBBELAAR AND F.C. STEWARD, J]. Am. Chem. Soc., 75 (1953) 4341. 
18 N. GROBBELAAR AND F. C. STEWARD, Nature, 182 (1958) 1358. 
19 A.C. HULME AND F. C. STEWARD, Nature, 175 (1955) 703. 
20 J. K. MietTINEN, Ann. Acad. Sci. Fennicae, Ser. A. II., 60 (1955) 520. 
20a K. MotueEs, (subed.), Encyclopedia of Plant Physiology: Nitrogen Metabolism, Vol VIII, (1958). 
21 F. F. NoE anpD L. FowbeEn, Nature, 184 (1959) B.A. 69. 
22 J. K. PoLtarpD, E. SONDHEIMER AND F.C. STEWARD, Nature, 182 (1958) 1356. 
23 J. K. POLLARD AND F. C. STEWARD, J. Exptl. Botany, 10 (1959) 17. 
24 FE. ROBERTS AND H.M. Brecorr, J. Biol. Chem., 201 (1953) 393- 
25 H.N. RYDON AND P. W. G. Situ, Nature, 169 (1952) 922. 
26 D. H. SpAcKMAN, W. H. STEIN AND S. Moore, Anal. Chem., 30 (1958) 1190. 
27 F.C. STEWARD, R. G. S. BIDWELL AND E. W. YEmM, Nature, 178 (1956) 734, 789. 
28 F.C. STEWARD AND J. K. PoLiarp, in W. D. McELRoy anv B. Grass (Eds.), Inorganic Nitrogen 
Metabolism, The Johns Hopkins Press, Baltimore, 1956, p. 377. 
29 F.C. STEWARD AND J. K. PoLLtarp, Ann. Rev. Plant Physiol., 8 (1957) 65. 
30 F.C. STEWARD AND J. F. THompson, Ann. Rev. Plant Physiol., 1 (1950) 233. 
31 F.C. STEWARD AND H. E. STREET, Plant Physiol., 21 (1946) 155. 
32 F.C. STEWARD, R. H. WETMORE AND J. K. Potrarp, Am. J. Botany, 42 (1955) 946. 
33 F. C. STEWARD, R. M. ZACHARIUS AND J. K. Pottarp, Ann. Acad. Sci. Fennicae, Ser. A. II., 60 
(1955) 321. 
34 J. F. THompson, J. K. POLLARD AND F. C. STEWARD, Plant Physiol., 28 (1953) 401. 
35 A. JT. VIRTANEN AND P. K. HiEetTara, Acta Chem. Scand., 9 (1955) 175- 
36 R. M. Zacuarius, Ph. D. Thesis, University of Rochester, Rochester, N.Y. 1952. 
37 R. M. ZAcHARIUS, J. F. THompsSON AND F. C. STEWARD, J. Am. Chem. Soc., 74 (1952) 2949. 
