AMINO ACIDS IN PRE- AND POST-NATAL PERIODS 277 
7. Different poisons 
To conclude this brief summary I should like to mention hyperaminoaciduria caused 
by various poisons. This is true for lead, cadmium, uranium and other heavy 
metals!84, 238, 239; for sodium fluoride, dinitrobenzene, lysol, maleic acid?#0, 241, 244, 
succinic acid, y-butyrobetaine?*”, oxalic acid*48 and also for amino acid antagonists”. 
Large amounts of amino acids particularly cystine, methionine and lysine lead 
not only to high excretion rates of the respective amino acid, but also of many 
others®’, 246-248. This is apparently due to a competitive or non-competitive inhibi- 
tion of the transport mechanism. Some amino acids may even damage the tubuli 
irreversibly”4®. According to VAN CREFELD?*® toxic amounts of vitamin D produced 
in one child a severe hyperaminoaciduria. In our three cases and also in those of 
WEWALKA”! no significant increase of the amino acids in urine could be detected. 
Severe shock syndromes, for instance, those due to burns?*?: 63, surgical trauma‘s 
and accidents?*4-256, evoke a temporary hyperaminoaciduria. The same is true 
for severe infectious diseases®; 2°. The results of amino acid studies in the different 
virus and bacterial infections vary greatly. This is to be expected, since so many 
divergent factors may play a role in influencing amino acid excretion. 
TABLE V 
FREE AMINO ACIDS IN LIQUOR CEREBROSPINALIS OF HEALTHY HUMAN BEINGS 
Average values in mg% 


AUTHOR Murine et al.28° Torre et al.28° LocotHetis?®3 WaAvker et al.27® Huisman??? SoLomon et al.?78 

Column chro- Miserabial: 
Me A , 
Tethod Paper chromatography matography 

Aspartic acid O:13 — o.11 0.04 0.10 — 
Glutamic acid 0.2 0.50-1.76 0.09 0.00 3.35 — 
Lysine 0.36 —- 0.17 —= 0.20 0.28 
Arginine 0.20 0.07—0.13 0.16 = 0.10 0.60 
Histidine 0.20 0.07—0.55 — = 0.05 0.17 
Tyrosine 0.18 0.10—0.90 0.16 0.08 0.10 0.20 
Tryptophane 0.20 0.20—0.33 —— — = = 
Phenylalanine 0.19 0.07—0.15 0.18 O21 0.15 0.19 
Hydroxyproline oO — — — = ae 
Proline 0.27 — — — — — 
Cystine 0.24 0.10—-0.55 — — 0.05 0.18 
Methionine 0.13 — — — 0.05 0.04 
Leucine 0.2 0.05—0.42 0.14 0.14 0.05 0.14 
Isoleucine 0.12 — — —— — 0.095 
Valine 0.36 0.05—-0.41 0.12 0.07 0.15 0.21 
Glycine 0.39 0.05—0.18 0.09 0.10 0.10 — 
Alanine 0.34 0.05—0.17 0.15 O.11 0.15 = 
Serine 0.28 — 0.22 0.16 0.10 — 
Threonine 0.18 _— 0.12 0.13 0.30 0.28 
Taurine 0.32 == == = = = 
Glutamine 0.45 — 0.30 0.71 = = 
a-Aminobutyric acid traces = 0.02 = as = 
y-Aminobutyric acid traces = 0.04 —— = aa 


References p. 279/283 
