406 G. ROUSER et al. 


emai et, 3 —_ | 
Figs. 169-180. Tissue samples (extracts of 50 mg) from control and mustard treated rabbits 
(4 days after drug administiation). Figs. 169-171, from kidney, spleen, and bone marrow of a 
control; Figs. 172-174, from kidney, spleen, and bone marrow after 2.5 mg/kg of mustard; 
Figs. 175-177, from kidney, spleen, and bone marrow from another animal after 2.5 mg/kg of 
mustard; Figs. 178-180, prepared from kidney, spleen, and bone marrow after 1.0 mg/kg of 
mustard. 
Figs. 181 and 182. From 0.3 ml of erythrocytes of a rabbit prior to and 5h after injection of 
nitrogen mustard. Note increase in glutathione (indicated by arrows) in the 5-h sample. For 
abbreviations see p. 369. 
observed in animal R-r1 that received 2.5 mg/kg of mustard. Fig. 192 shows the con- 
trol plasma and Fig. 193 the 3 day plasma sample from this animal. All free amino 
acids except glutamic acid were greatly reduced. All of the animals in the 2.5 mg/kg 
group showed more pronounced changes than those in the 1.0 mg/kg group and no 
difference in the response of males or females was observed. 
The hematological responses of the animals are shown in Fig. 183. The response 
is in full agreement with the findings of WEISBERGER AND HEINLE?!. The means of 
the counts in each group are shown. There was a steady fall in the hematocrit value 
throughout the course of study. Part of this erythrocyte loss can be attributed to 
References p. 447/448 
