4260 G. ROUSER, K. KELLY, B. JELINEK, D. HELLER 
250 | 



252 

' 
3S. 250-267. Extracts of 0.3 ml of plasma from patient R. Tap. after drug administration. 
Figs. 250-253, plasma 4, 7, 17, and 74 days after 40 mg of dimethylmyleran. Figs. 254-259, 
plasma 1, 14, 28, 42, 61, and 85 days after 30 mg of dimethylmyleran. Figs. 260-266, plasma 
after myleran (10 mg/day for ro days). Fig. 267, changes produced by injection of the isomeric 
dimethylmyleran (CB 2432). See text for discussion. For abbreviations see p. 369. 
Little or no change is observed in free amino acid levels when the leukocyte count is 
not affected. The most marked changes in free amino acids are observed at the higher 
dosage levels when the white cell count is reduced to the lowest level. The relatively 
inactive pentane myleran that failed to produce a drop in leukocyte count failed to 
produce any changes in the free amino acid levels. The leukocyte count of a patient 
with chronic lymphatic leukemia did not decrease after the injection of dimethyl- 
myleran and only very minor changes in blood free amino acids were observed. 
References p. 447/448 
