460 E. V. FLOCK AND J. L. BOLLMAN 
is apparent between the symptoms or survival time and the free amino acids of the 
brain. This suggests that these substances are not directly toxic to the brain. It is 
probable, however, that toxic substances do accumulate in the brain and account 
for the hepatic coma which develops within 1-2 days after removal of the liver and 
rapidly becomes fatal. It is also possible that a deficiency of some essential nutrient 
of the brain normally furnished by the liver develops and becomes a limiting factor 
in the survival of these animals. © 
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