PSYCHOTROPIC DRUGS AND THE METABOLISM OF BRAIN 495 
mately equals the value found after dissection of the cortex. After metabolism under 
O,, with 1 mM Ca in the buffer (Tables I and II), this value is lower. 
After metabolism under 100°, N, the amino acids are not resorbed while the GABA 
and Glu content of the medium far exceeds the value found after dissection of the 
control animals, the tissue being entirely depleted. 
wg AS 2 ea 
ou 
Trihexyphenidy| (Artane®) Procycline (Kemadrin ®) 
\ / as Cr 
CHe  N Oo, CH2 CH3 
A Ne Ga ‘ES SN 
aks Enis wi 
Cycrimine(Pagitane ®) Orphenadrine 
Fig. 1 
The same picture is obtained if orphenadrine and chlorpromazin, are added at 
concentrations of 2m/M/. 
In both cases the depletion of the tissue is attended with inhibited oxygen 
consumption (60 and 94%, respectively). 
However, after phenobarbital, at the same concentration, GABA and Glu are 
Boae cH GHs 
2 CH3 On. oN a CH3 
eo, i 
Diphenhydramine Orphenadrine 
Ho ANNs oO. CHa (CH3 
CoHs ee NAS NN i Cc” ‘CZ SNC 
N= = CH3 N= ite CH3 
YJ \_ / 
Azabenzhydrylether Azabenzhydrylether 
Fig. 2 
resorbed while the oxygen consumption is inhibited by 34%. The same effect is 
observed after Diamox ®, which does not affect the oxygen consumption. This led us 
to assume that a correlation existed between the highly inhibited oxygen consumption 
and the fact that the amino acids are not resorbed. 
However, comparison of orphenadrine with a number of clinically useful Parkin- 
References p. 498 
