730 H. WAELSCH 
mm vivo. Future studies will provide many more examples of the compartmentation 
of metabolism and of the modification of metabolic compartments under various 
physiological and pathological conditions. The concept of metabolic compartments 
removes the dichotomy between structure and metabolism and, we hope, also between 
metabolism and function. The isotope technique may be used in order to study 
metabolic compartments 7m vivo and characterize the intermediary metabolism of 
various organs in a novel way. It is surely not a matter of chance that the question 
of integration of structure and metabolism became most urgent in the central 
nervous system and stimulated our laboratory to embark on these investigations. 
ACKNOWLEDGEMENTS 
The work from the author’s laboratory described in this paper has been supported 
in part by grants (B-226 and B-557) from the National Institute of Neurological 
Disease and Blindness, U.S. Public Health Service, by contracts between the Office 
of Naval Research and the Air Force Office of Scientific Research and the Psychiatric 
Institute, and a grant from the Supreme Council, 33rd Scottish Rite Masons of the 
Northern Jurisdiction, U.S.A. 
REFERENCES 
1H. WaELscH, in F. BRUcKE, Biochemistry of the Nervous System, Proc. 4th Internatl. Congress 
Biochemistry, Pergamon Press, London, 1959, p. 36. 
H. Waetscu, in D. B. Tower Anp J. P. ScHapk, Structure and Function of the Cerebral Cortex, 
Elsevier Publishing Co., Amsterdam, 1960, p. 313. 
H. WaeEtscu, in S.S. Kety anp J. ELKes, Regional Neurochemistry; Regional Chemistry 
Physiology and Pharmacology of the Nervous System, Pergamon Press, London, 1961. 
A. Lajtua, S. Bert anpd H. WaeEtscu, in E. Roserts et al., Inhibition of the Nervous System 
and y-Aminobutyric Acid, Pergamon Press, London, 1960, p. 460. 
A. LajTHA, S. BERL AND H. WAELSCH, J. Neurochem., 3 (1959) 322. 
S. Beri, A. LaytHA AND H. WAELSCH, J. Neurochem., 1(1961)186. 
G. TAKAGAKI, S. BERL, D. D. CLarx, D. P. PurPURA AND H. WaE tscu, Nature, 189 (1961) 326. 
E. Roperts, in S. R. Korey anp J. 1. NURNBERGER, Neurochemistry, Hoeber-Harper, New 
York, 1956, p. If. 
J.P. Du RuissEeau, J. P. GREENSTEIN, M. WiniTz AND S.M. BirNBAUM, Arch. Biochem. 
Biophys., 68 (1957) 161. 
10 W. C. SCHNEIDER, Advances in Enzymol., 21 (1959) 1. 
11S. Bert, D. D. Clarke, G. TAKAGAKI, D. P. PuRPURA AND H. WaAEtscH, Federation Proc., 
20 (1961) 342. 
12S. BERL, D. P. PurpurA, M. GrrADO AND H. WAELSCH, J. Neurochem., 4 (1959) 311. 
13S. BERL, G. TAKAGAKI AND D. P. PuRPURA, J. Neurochem., 1(1961)198. 
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