780 
Alanine, (continuation) 
—, In nerve, 475, 477 
—, oxidation by liver and non-hepatic tissues, 
7LO me AIeL 
—, synthesis in plant leaves, 673 
—, transfer from pool to protein, 635 
—, uptake by bacterial protoplasts, 615 
f-Alanine, excretion, 462 
—, formation, 169 
—, in HeLa cells, 696 
—, human urine, 200 
—, rat liver, 503-505 
p-Alanine, occurrence in Oncopeltus fasciatus 
(milkweed bug), 121 
p-Alanyl-p-alanine, occurrence in Streptococcus 
faecalis, 89, 90 
Albumen proteins, transport, 298 
Alcaligenes faecalis, methionine accumulation, 
572, 577 
Alcaptonuria, amino acid excretion in, 255 
Aldolase, glycine, turnover, 683, 684 
Allantoic acid, importance in plant metabolism, 
667 
Allantoin, importance in plant metabolism, 667 
Alligator, muscle, serine ethanolamine phos- 
phodiester in, 187 
—, yp-L-glutamyl-L-phenylalanine in, 55 
Allium cepa, y-L-glutamyl-S-(f-carboxy-N- 
propyl) cysteinylglycine in, 55 
—, y-glutamylvaline and y-glutamylisoleucine 
in, 56 
—, S-n-propyl-L-cysteine sulfoxide in, 43, 44 
Allo, definition, 71 
Allohydroxylysine, separation from hydroxy- 
lysine, 12 
Allohydroxyproline, separation from hydroxy- 
proline, 12, 13 
Alloisoleucine, separation from isoleucine, 12 
13 
p-Alloisoleucine, excretion, 515 
Allothreonine, separation from threonine, 12, 
13 
Alloxan diabetes, plasma amino acids in liver 
perfusion, 715 
Amblystoma punctatum, egg, amino acids in, 
during development, 298 
Amidase, use in resolving amino acids, 13-15 
Amides, substituted metabolism, 48 
Amines, binding to cell fractions, 771, 772 
—, brain, effect of drugs on, 489, 490 
—., in invertebrates, 170, 171 
—, occurrence in plants, 41 
Amino acid(s) activation, during transport, 540 
antagonists, effect on urine amino acids, 277 
—, combined, in urine, 228 
—, criteria for occurrence in protein, 5 
— decarboxylases, use in determining optical 
configuration, 17 
—, essential, excretion in urine, 196 
—., free, criteria for occurrence, 6 
—, — occurrence, historical, plants, 25 
— imbalance, 519-521, 524 
—, lipid (see Lipid—amino acid) 
—, occurrence in phospholipids, 121 
2 

SUBJECT INDEX 
Amino acid(s), (continuation ) 
— oxidation, role of liver, 708, 709 
— pool, active and inactive, 674 
, association with intracelluar com- 
ponents, Io1 
— —, — with nucleic acid, ror 
— —, bacteria, effect of age, 80 
— —, binding of, 641 
— —, — amino acids, 688 
— —, in blood fractions, effect of leukemia, 
385-387 
— —, buffering action, 130 
— —, by-pass, 591 
— —, Capacity in microorganisms, 569-571 
— —, change in specific activity, 740, 741 
— —, — during development, 298-306 
— —, characteristic in tissues, 285-287 
— -—, comparison marine and fresh water 
organisms, 161 
— —, — of size, in bacteria, 79 
——., contribution from protein turnover, 
704 
— —, definition, 595, 596 
— —, dependence on genetic constitution, 83 
— —, depletion, effect on intracellular 
structure, 697, 698, 700, 701 
— —, developmental aspects, 124-129 
— —, difference in Gram-positive and -nega- 
tive bacteria, 78, 79, 80, 102, 569-571 
— —, — in sexes, 118 
— —, differential extraction, 655 
— —, displacement from, 571 
— —, effect of age, 93-95 
— —, — carbon source, 97 
— —, — environment, crab, 161 
— —, — extracellular fluid, 510, 511 
— —, — extracellular protein, 706 
— —, — germination in Tvilletia caries, 86 
— —, — growth medium on, 96 
— -—, — hydrostatic pressure on, IOI 
— —, — inhibitors on, 99 
— —, — inorganic nitrogen on, 97 
— —, — mutation, 129 
— —, — nutritional deficiencies, 96, 97 
— —, — osmotic factors, 598, 601, 606 
—-—, — osmotic strength on size, 102, 
571, 574, 575, 581-583 
— —, — salinity, crab, 161 
— —, — starvation, 171, 173 
= —, wenn earehabhde,, ait 
— —, endogenous respiration and, 102, 103 
— —, exchange, 596-598, 600, 601, 604, 605, 

569, 
— —, expandable, 571, 575, 638, 640 
— —, —, properties, 640, 641 
— —, experimental alteration, 306-346 
-, extent of binding, 766 
— —, extraction, 289, 517 
— —, — from blood cells, 353 
— —, — from protozoa, 109 
— —, extraction procedures, 101 
-, in fishes, size of, 160 
— —, formation, Candida utilis, 638 
— —, —, carrier model, 603—608 
, 
