[mills] functional DEVELOPMENT OF CEREBRAL CORTEX 7 



III this ease there seemed to be rough localization, thougli a very strong 

 cunent is required ; the hind-leg responds most readily ; in fact, the fore-leg 

 is uncertain. 

 Case Vlll.—Crosfi-brcd dog puppy of same litter ; 17th rfa*/.— Ether. 



With current B get decided movement of fore-leg and head, but can not 

 get these repeated ; hind-leg movement distinct. Remove cortex over one 

 motor area (and more) thoroughly, then, on stimulation with the same current, 

 get movement of fore-leg twice, but after these it is impossible to get move-, 

 ment with any strength of current. The wound is closed by sutures and with 

 some regard to antisepsis. These the dam removes the same evening. There 

 is later some suppuration and granulations appear. The puppy couid suck, 

 lap milk, and never at any time manifested signs of paralysis, etc. It seemed 

 to move as usual. Four days later (i. e., when 21 days old), the skull is again 

 opened, when, on stimulated over the motor area of the till now intact side, 

 movements of the fore-limb and head are readily produced, but of the hind- 

 limb somewhat indifferently. These movements may be more fully described 

 thus : 



1. AVith current B head is moved upward (or backwards), and, of course, to 

 the opposite side. This results with this strength of current over an area 

 extending in a curve around the outer extremity of the crucial sulcus. 



2. Movements of the fore-leg, both extension and flexion of the paw, i. e., 

 sometimes one and sometimes the other, when an area a little more extensive 

 than the original one is stimulated. 



3. To get movement of the hind-leg in this case a stronger current is 

 required, and the result follows whether the stimulus be applied to the crucial 

 sulcus itself or behind it and as near the middle line as the centre for the 

 fore-limb. 



Case IX. — Mongrel pupjiy ; 10th day. — Eyes not open. Ether. 



No reaction to any strength of current applied over the greater part of the 

 ' cortex of both sides. On removal of the cortex over the motor area very freely 

 movements of the hind-leg are produced by stimulation on three successive 

 trials ; after this, no result of a positive kind. 



Case X. — Mongrel puppy of the same litter ; 12th fZa(/.— Eyes open. 



With current B, aiovement of the hind-leg ; no other movements with any 

 strength of cuivrent and none when the cortex removed. The animal, however, 

 was then considerably depressed. 



Case XI. — Mongrel 2iuppy of same litter as last ; loth day. — Eyes open. Ether. 



With current C gee movements of the hind-leg, but no others till the cortex 

 is removed ; then hind-leg movements were again produced, and movements 

 of the toes of the fore-leg. On trying the opposite side (cortex), with the 

 same rather strong current applied to adjacent areas, movements of both the 

 fore-leg and the hind-leg follow. In this case the movements are equally good 

 for both legs at first, but they persist longest for the hind-leg. 



Case XII. — Mongrel 2iuiypy ; 14th day. — Eyes open. Ether. 



With current B, movement of the hind leg ; the same result on stimulat- 

 ing the opposite side of the brain ; after a few stimulations, no movement. 

 The cortex is removed; movement of the hind-leg is then produced. At a 

 point more forward get movement of the head to the opposite side ; and 

 further to one side, movement of the fore-leg. 



Case XIII. — Mongrel puppy ; 20fh day. — Ether. 



Much haemorrhage when attempting to reach the right side of the cortex. 

 This side refractory to stimulation. Then quickly exposed the left side; brain 

 is very pale ; can get movement of the hind-leg only. No result on sinking 

 the electrodes into the white matter through the cortex. 



