CONTENTS XI 



Page 



D. Of Ruminants 521 



Thomas H. Jukes and William L. Williams 



E. Of Human Beings 522 



Frank H. Bethell 



CHAPTER 4. BIOTIN 525 



I. Nomenclature and Formula 526 



Robert S. Harris 



II. Chemistry 527 



Paul Gyorgy 



III. Industrial Preparation 572 



Paul Gyorgy 



IV. Biochemical Systems 575 



Paul Gyorgy 



V. Specificity of Action 586 



Paul Gyorgy 



VI. Biogenesis 587 



Paul Gyorgy 

 VII. Estimation 588 



A. Bioassay Using Higher Animals 589 



Paul Gyorgy 



B. Microbiological Estimation 593 



Esmond E. SxNEll 



VIII. Standardization of Activity 595 



Paul Gyorgy 



IX. Occurrence in Food 595 



Paul Gyorgy 



X. Effects of Deficiency 600 



Paul Gyorgy 



XI. Pathology 613 



Paul Gyorgy 



XII. Pharmacology 614 



Paul Gyorgy 



XIII. Requirements 615 



Paul Gyorgy 



Author Index 619 



Subject Index 655 



