\ll. \ll \M1\ \ Di;!'!!!!^!^ IN ANIMALS 



i:-;i 



shown ill \crtcl)r;u' and l)i)ii('s ol' the skull, indudiiiji those of rcplaccincnl 

 oi'ijiin (l''i.a;s. H, I'J, and \'A). 



In chihh'cn and intants hone chanjics, thus far studied only hy x-ray, 

 aie associated with painful swellintis o\-er lon<>- l)ones. All the nunierou.s 

 patients studied had icceixcd lish li\-ei- oil concentrates containini^ a largo 



Fig. 42. Vitamin A deficiency in the chick. X'crtcl)!-;!. niidijortioii of rhomlioidal 

 fossa. Note inactive epiphyseal cartilages and charactci' of tlie cancellous hone. 



amount of vitamin D, which must l)e taken into account in consideration 

 of the fact that the outstanding fin(Hng has been midshaft cortical hyper- 

 ostoses of long bones, not correlatable with normal growth patterns and 

 roentgenologically similar to "infantile cortical hyperostosis" of unknown 

 etiology. Peihaps coii-elatable with normal growth are two other roentgeno- 

 logical findings, earl>- format ion of centers of ossification in achance of chron- 

 ological age,''" and irregulai' out lines of epiphyses,^*'- both not conspicuous.^^- ■^'^ 



" n. W. Josepliis. .1///. ./. I),s,as,s Chihlnn 67. :« (1944). 



's C. T. Fried and M. .1. II. (Irand, .1///. ./. I)isr„xes Childirn 79, 475 (1950). 



