132 



VITAMINS A AND CAROTENES 



111 no reported human case did daily ingestion of \'itamiii A approximate 

 the amounts used in the animal experiments described, and several to 

 many months were reciuired to elicit "toxic" signs of hypervitaminosis. 

 Accumulative storage of vitamin A in the liver and the effects of excessive 



Fji.. lo. .\i)iiii;il rliick vertebral bone. 



intake of vitamin D and possibly other substances in the fish liver oil 

 concentrates require consideration in appraisal of current meager informa- 

 tion on the pathology of hypervitaminosis A in humans. 



Two, as yet inexplicable, effects of vitamin A upon bone removed from 



33 J. Caffey, Am. J. Roentgenol. Radium Therapy 65, 12 (1951). 



^0 D. Gribetz, S. H. Silverman, and A. E. Sobel, Pediatrics 7, 372 (1951). 



