II. CHEMISTRY 



569 



TABLE V"* 



HOMOLOGS AND SULFONE ANALOGS OF BlOTIN 



Compound 



Organism 



Molar inhibition ratio 



Biotin 



Destheiobiotin References 



" Also inhibitory for L. arabinosus and Staphylococcus aureus. 

 * A mutant strain requiring biotin or desthiobiotin for growth. 



TABLE VII" 

 Analogs of Oxybiotin 



[3,4iimida2ole-4-(4-butane- 

 sulfonic acid) (oxybiotin sul- 

 fonic acid) 

 dl- Hexah y dro-2-oxo-4-(4-ben- 

 zylthiobutyl)-lH-furo[3,41- 

 imidazole 



Saccharomyces cerevisiae 



740,000 



9,300 



76 



175 



" No significant inhibition. 



of the yeast cells when given to the culture before the addition of biotin or 

 o.xybiotin, with inhibitory ratios of 3750 and 5000, respectively, for oxy- 

 biotin, and 375,000 and 600,000 for biotin. No inhibition is observed when 



"* M. W. Goldberg, L. H. Sternbach, S. Kaiser, S. D. Heineman, J. Scheiner, and 



S. H. Rubin, Arch. Biochem. 14, 480 (1947). 

 '7* A. E. Axelrod, S. E. Purris, and K. Hofmann, J. Biol. Chem. 176, 695 (1948). 



