658 



SUBJECT INDEX 



Biotin, 457, 518 

 analogs, 



affinity for avidin, 557-558 



biological activity of, 564 



inhibition by, 566-571 



synthesis of, 549-552 

 a- and /3-forms of, 542-543 

 biochemistry of, 575-587 

 biogenesis of, 587-588 

 chemistry of, 527-571 

 in citrulline synthesis, 581 

 complexes of, 553-558 

 constitution of, 532-543 

 coprophagy and, 588 

 deficiency, 



effects of, 600-603 



in cattle, 603 



in chickens, 602-603 



in dogs, 603 



in fish, 603-604 



in humans, 604-606 



in mice, 600-602 



in monkeys, 604 



in rats, 600-602 



in swine, 603 



in turkeys, 602-603 

 differentiation from oxybiotin, 561 

 effect, 



on "malic" enzyme, 578-579 



on plants, 588 

 estimation of, 588-595 



chick method, 593 



microbiological method, 593-595 



preparation of samples, 594 



rat method, 589-593 

 excretion of, 587 

 in deamination, 582-584 

 fatty liver and, 606-608 

 in hydrogen transport, 585-586 

 industrial preparation of, 572-574 

 in infectious disease, 611-613 

 isolation of, 527-531 

 nomenclature, 526 

 occurrence in food, 595-599 

 pantothenic acid and, 601-602 

 pathology of, 613-614 

 pharmacology of, 614-615 

 properties of, 531-532 

 radioactive, 579-580 

 requirements. 



of insects, 617-618 



of mammals and birds, 618 



of microorganisms, 615-617 



sex hormones and, 608-609 



side chain of, 535-537 



sources of, 587 



specificity of, 558-571, 586-587 



standardization of, 595 



stereoisomers of, 546 



structure of, 527, 541 



synthesis of, 544-549 



tumors and, 609-611 



urea ring of, 537-539 

 Biotin hydrazide, 536 

 Biotinol, 



biological activity of, 559 

 Biotin sulfone, 561 



as inhibitor, 567 



biological activity of, 562-564 



formation of, 534 

 Biotin sulfoxide, 



biological activity of, 564 



effect on biotin assay, 594 

 e-A'^-Biotinyl-L-lysine, 554 

 Biotoprotein, 555, 575 

 Bitot's spots, 143, 144-145, 146 

 Bladder, 299 

 Blindness, 



in vitamin A deficiency, 110-111 

 Blood coagulation, 



in scurvy, 292-294 

 Blood, 



in scurvy, 289-294 



vitamin A assay of, 96-97 

 Blood esterase, 



ascorbic acid and, 238 

 Blood pressure, 



in scurvy, 289 

 Blood volume, 



in scurvy, 289-290 

 "Blue-slime" disease, 603 

 Bones, 



in hypervitaminosis A, 125-133 



in scurvy, 281-282, 359 



in vitamin A deficiency, 116-119 

 Bronchiectasis, 111 

 Buffers, 



in vitamin B12 extraction, 472 

 Bush sickness, 521 

 Butyric acid, 581 



