666 



SUBJECT INDEX 



Intercellular cement, 



in scurvy, 287-288 

 Intestinal microorganisms, 



biotin synthesis by, 587, 589, 593 



in vitamin B12 production, 447-448, 

 522-523 

 "Intrinsic factor", 506, 507 



extragastric, 496 



in pernicious anemia, 493-496 



in tapeworm infestation, 502 

 Intestine, 299 



in vitamin deficiency, 502-503 

 lodate, 248 

 Iodine, 



in ascorbic acid estimation, 248 

 lodoacetate, 69 

 lodopsin, 



nature of, 59 



specificity of, 61 



synthesis of, 82 

 a-Ionone, 34 



/3-Ionone, 4, 9, 21, 32, 33, 34, 35, 42, 55 

 /3-Ionylidene acetaldehyde, 25 

 Iron, 255 



ascorbic acid and, 224, 225, 246, 254, 

 323, 379 



in scurvy, 371 



in vitamin B12 assay, 462 



papain and, 239 

 Isoanhydrovitamin A, 



preparation and properties, 50 

 Isoascorbic acid, 253, 255, 313-314 

 Isocitric acid, 235 

 Isogeronic acid, 55 

 Isooleic acid, 



in biotin replacement, 565 

 Isoretinenes, 



in rhodopsin synthesis, 79, 80 

 Isorhodopsin, 80 

 Isovaleric acid, 581 



Keratinization, 



in vitamin A deficiency, 107-110, 111, 

 112, 140-141 

 Keratomalacia, 111, 141, 142 



early investigations of, 143-144 



external manifestations of, 144-145 



histopathology of, 145-147 



response to therapy, 147 

 Keratosis follicularis, 159, 300 



Keratosis pilaris, 154 

 2-Keto-D-gluconic acid, 194, 196 

 a-Ketoglutaric acid, 313 



biotin and, 577-578 

 2-Keto-L-gulonic acid, 211, 215 



formation from sorbose, 210 



in ascorbic acid synthesis, 191, 194, 

 195, 196, 209 

 2-Keto-L-gulosaccharic acid, 195 

 2-Keto-L-idonic acid, 



in ascorbic acid synthesis, 209 

 Kidney, 299 

 Kidney dysfunctions, 



vitamin A and, 175 

 Kitols, 



occurrence of, 105 



relation to vitamin A, 20-21 



Laccase, 225 



in ascorbic acid oxidation, 227 

 D-Lactamide, 407 

 Lactation, 



ascorbic acid requirement in, 386, 390 



biotin and, 601 

 Lactic acid, 66, 69 



in dehydroascorbic acid reduction, 236 



oxidation of, 229-230 



in scurvy, 317 

 Lactic dehydrogenase, 230 

 Lactobacilli y 



response to biocytin, 553 

 Lactobacillus arabinosus, 512 



in biotin assay, 593-595 

 Lactobacillus lactis, 489 



in vitamin B12 assay, 397, 398, 407, 414, 

 455-459, 466-467, 475 

 Lactobacillus leichmannii, 443, 477, 485, 

 487 



in vitamin B12 assay, 408, 457-465, 467, 

 473-476 

 Lactose, 



effect on biotin sj-nthesis, 588 

 Lambert-Beer law, 87-88 

 Laurie acid, 



in biotin replacement, 565 

 Lecithin, 304, 317 



in biotin replacement, 564, 617 

 Leiner's disease, 



biotin and, 600, 605-606 



