Vm. EFFECTS OF DEFICIENCY 37 



B. IN ANIMALS 



1. Rats 



The discovery by Woods and Fildes*^' that PABA is somehow concerned 

 in bacterial metabolism served as the impetus for studies on the significance, 

 if any, of this compound in animal nutrition. Ansbacher^^ in 1941 concluded 

 that PABA is a "vitamin," since its oral administration at a level of 3 mg. 

 per day to black or piebald rats that had become gray on a purified basal 

 diet containing pantothenic acid was accompanied by a return of the fur 

 to normal pigmentation. Untreated controls continued to show typical 

 achromotrichia. These observations appeared to contradict much contempo- 

 raiy evidence that pantothenic acid deficiency alone is responsible for nu- 



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