XI. PHARMACOLOGY 61 



et a/.'"'* Clinical verification has been reported by Anigstein and Bader/*" 

 Rose et a/.,'"- 'rierney,'"' Faust,'"" Smith,'"* Levy and Arnold,""' Maroney 

 et a7.,'"' Ravenel,'"'^ Snyder et a/.,'"-' and Hendricks and Peters."" 



Faust states that PAH.V may be considered as relatively specific in the 

 treatment of the tyjihus grouj) of di.seases when given in the first week 

 following on.set of infection. Dosage is very large. Uavenel specifies that 

 i)lood levels of 30 to GO mg. j)er 100 ml. are desirable and that GO to 80 

 mg. per 100 ml. may l)e necessary in some cases. Levels above 80 mg. 

 per 100 ml. of blood are dangerous. Alkalies also are necessary to i)revent 

 acidosis. Under this regimen, a practical guarantee may be given that 

 fatality will not occur. 



4. Neoplastic Diseases 



Burk et aZ."' found that PABA exerted an anticarcinogenic action on the 

 production of hepatomas of rats fed p-dimethylaminoazobenzene and 

 excess biotin. Large doses of PABA produced a striking lowering of leuco- 

 cyte counts of six patients with chronic or subacute myelogenous leu- 

 kemia. "^ Less definite decreases in leucocyte counts occurred in cases of 

 chronic lymphatic leukemia. Prompt rise in counts followed discontinua- 

 tion of therapy. The use of PABA did not appear to be a practical form 

 of treatment. 



o. Other Diseases 



Dry et aZ."^- "" reported the use of PABA to raise and maintain the blood 

 level of salicylates in patients with acute rheumatic fever. PABA alone 



100 H. L. Hamilton, H. Plotz, and J. E. Smadel, Proc. Soc. Exptl. Biol. Med. 58, 255 

 (1945). 



101 L. Anigstein and M. N. Bader, Science 101, 591 (1945). 



102 H. M. Rose, R. B. Duane, and E. E. Fischel, /. Am. Med. Assoc. 129, 1160 (1945). 



103 N. A. Tierney, /. .4m. Med. Assoc. 131, 280 {\9A6) ; Southern Med. J. 40, 81 (1947). 

 10^ E. C. Faust, J. Am. Med. Assoc. 132, 965 (1946). 



105 P. K. Smith, J. .4m. Med. Assoc. 131, 1114 (1946). 



106 M. D. Levy and W. T. Arnold, Texas Stale J. Med. 42, 314 (1946). 



107 J. W. Maroney, H. C. Davis, and E. G. Scott, Delaicare State Med. J. 18, 104 (1946). 

 los S. F. Ravenel, J. Am. Med. Assoc. 133, 989 {I9i7); Southern Med. J. 40, 801 (1947). 

 io« J. C. Snyder, A. Yeomans, D. H. Clement, E. S. Murray, C. J. D. Zarafonetis, and 



N. A. Tierney, Ann. Internal Med. 27, 1 (1947). 



110 W. J. Hendricks and M. Peters, /. Pediat. 30, 72 (1947). 



111 D. Burk, J. M. Spangler, V. du Vigneaud, C. Kensler, K. Sugiura, and C. P. 

 Rhoads, Cancer Research 3, 130 (1943). 



11- C. J. D. Zarafonetis, O. A. Andrews. M. C. Myers, and F. H. Bethell, Blood 3, 



780 (1948). 

 11^ T. .1. Dry, Proc. Central Soc. Clin. Research 19, 69 (1946). 

 i" T. J. Dry, H. R. Butt, and C. H. Scheifley, Proc. Staff Meetings Mayo Clinic 21, 



497 (1946). 



