TABLE IX 



Sulfonamide Reversal by Derivatives of p-Aminobenzoic Acid 



Compound 



Species 



Activity, 

 of PABA, 



% Reference 



p-Aminobenzoic acid 



0- and m-Aminobenzoic acid 



Ethyl p-aminobenzoate 



Diethylaminoethyl p-aminobenzoate 



(procaine) 

 Dimethylaminoethyl p-(n-butylamino)- 



benzoic acid (pantocaine) 

 p-Aminobenzamide 

 p-Aminobenzoylglycine 

 p-Nitrobenzoic acid 

 p-Hydroxylaminobenzoic acid 

 p-Hydroxybenzoic acid (POB) 

 p-Acetamidobenzoic acid 

 p-Aminophenylacetic acid 



2-Chloro-4-aminobenzoic acid 



2-Fluoro-4-aminobenzoic acid 

 2-Bromo-4-aminobenzoic acid 



2-Iodo-4-aminobenzoic acid 

 2-Hydroxy-4-aminobenzoic acid (PASA) 

 4-Aminoisophthalic acid 



2-(p-Aminobenzamido) pyridine 

 2-Aminopyrimidine-5-carboxylic acid 

 3-Methyl-4-aminobenzoic acid 

 p-(p-Amidobenzamido) benzoic acid 



p-Aminocinnamic acid 



4- ( p- Hydroxy phenyl) azobenzoic acid 

 p-Aminobenzoic hydrazide 

 N-Glucosido-p-aminobenzoic acid 

 Ethyl p-(N<-acetylsulfanilamido)ben- 



zoate 

 p-Aminophenylglycine 



4-Aminocyclohexanecarboxylic acid 

 p-Toluic acid 

 p-Ethylaminobenzoic acid 

 p-n-Butylaminobenzoic acid 

 3-Dimethylamino-l,2-dimethylpropyl- 



p-aminobenzoate (tutncaine) 

 5-(p-Aminobenzoxyethyl)-4-methyl 



thiazole 

 Ethyl N-(p-aminobenzoyl)alanine 

 p-Aminobenzenestibonic acid 

 Trimethylbetaine of p-aminobenzoic acid 

 Trimethylbetaine of sulfanilic acid 



Sir. hemolyticus, Diplococcus pneumo- 

 niae, Staph, aureus, Lactobacillus ara- 

 binosus 



Str. hemolyticus 



Str. pyogenes 



E. coli 



Str. hemolyticus 



E. coli 



E. coli 



Str. hemolyticus 



E. coli 



Str. hemolyticus 



Str. hemolyticus 



Str. hemolyticus 



Str. hemolyticus 



Str. hemolyticus, Diplococcus pneum.o- 



niae, E. coli, Staph, aureus 

 Clostridium acetobutylicum 

 Str. hemolyticus 

 Str. pyogenes 

 Diplococcus pneum.oniae 

 E. coli 

 E. coli 

 E. coli 



Diplococcus pneumoniae 

 E. coli 

 E. coli 

 Str. pyogenes 

 E. coli 



Sir. hemolyticus 

 Str. pyogenes 

 Str. pyogenes 

 Str. pyogenes 



Streptobacterium plantarum 

 Str. hemolyticus 

 Diplococcus pneumoniae 

 E. coli 



Str. hemolyticus, E. coli 

 Str. hemolyticus, E. coli 

 Str. hem.olyticus, E. coli 

 Str. hemolyticus, E. coli 



Str. hemolyticus, Diplococcus pneumo- 

 niae, Staph, aureus 

 Staph, aureus 

 Str. hemolyticus 

 Str. hemolyticus 

 Str. hemolyticus 

 Streptobacterium, plantarum 



Streptobacteritim plantarum 



Streptobacterium plantarum 

 Streptobacterium plantarum 

 Streptobacterium plantarum 

 Streptobacterium plantarum 



0.4S 



60 



72 



