XIV. rilKRAPEUTIC ACTIVITY 85 



thiounu'il jiroup, toxic doses would be necessary. It is concluded that 

 PABA is suitahio only for the treatment of mild cases of thyroidism. 



E. MISCELl.AXEOrS DISEASES 



The elYectiveness of PABA in the treatment of rickettsial diseases, 

 rheumatic fever, and related rheumatic iliseases is uneciuivocal. Results 

 that may he summarized as encouraging^, at best, have been obtained in llie 

 treatment of the followino- conditions with PABA: lymi)hoblastoma 

 cutis,"'"'- lupus erythematosus,^-''^^ active dermatomyositis,^-- "•'■ "^ sclero- 

 tlerma,^'- "'- dermatitis herpetiformis,"- ^* chronic mj'^elogenous leukemia,'"-^^ 

 and ex{)erimental allergic encephalomyelitis."-* 



PABA has l)een found by a number of investigators to have a low or- 

 der of fungistatic activity.^""^^ 



" C. J. D. Zarafonetis, J. Lab. Clin. Med. 33, 1462 (1948). 



■2 C. J. D. Zarafonetis, Ann. Internal Med. 30, 1188 (1949) . 



■3 C. J. D. Zarafonetis, R. H. Grekin, and A. C. Curtis, J. Invest. Dermatol. 11, .359 



(1948). 

 '^ C. J. D. Zarafonetis, A. C. Curtis, and R. H. Grekin, Univ. Hasp. Bull., {Ann 



Arbor) 13, 122 (1947). 

 "5 C. J. D. Zarafonetis, Am. J. Med. 5, 625 (1948). 

 '6 C. J. D. Zarafonetis, G. A. Andrews, M. C. Meyers, and F. H. Bethell, Blood 3, 



780 (1948). 

 " H. B. May and J. Vallance-Owen, Lancet 255, 607 (1948). 

 's J. Bichel, Le Sang 21, 360 (1950). 

 '9 R. A. Good, B. Campbell, and T. A. Good, Froc. Soc. Exptl. Biol. Med. 72, .341 



(1949). 

 8«G. W. K. Cavill and J. M. Vincent, J. Soc. Chem. Ind. (London) 68, 189 (1949) 



[C. A. 43, 8443 (1949)]. 

 »'G. W. K. Cavill and J. M. Vincent, ./. Soc. Chem. Ind. (London) 67, 25 (1948) 



[C. A. 42, 4701 (1948)]. 

 «2 F. Serri, Acta Vitaminol. 2, 73 (1948) [C. A. 43, 1826 (1949)]. 

 "E. Biocca and C. S. Lacaz, Arquiv. biol. (Sao Paulo) 29, 151 (1945) [C. A. 40, 



5090 (1946)]. 

 «OI. xMilner, C. M. Christensen, and W. F. Geddes, Cereal Chem. 24, 507 (1947) 



[C. .1. 42. 1671 (1948)]. 



