182 PTEROYLGLUTAMIC ACID 



Further details of the blood picture may be obtained from the papers of 

 Wills and Stewart, ^'^ Langston et al.,^^ and Wilson et al}^ 



I). Oral Ledons 



Oral lesions, particularly of the margins of the gums, are one of the most 

 frequently observed signs of nutritional cytopenia in the rhesus monkey. 

 These have been described in detail by Day et al.,^° Langston et al.,^^ Chap- 

 man and Harris, ^^ and Saslaw et al.^"^ The oral lesions develop shortly after 

 the onset of leucopenia and begin as a recession of the gums which develops 

 into a yellowish ulceration. The ulceration usually develops among the in- 



I 



Fig. 13. Gum lesions in vitamin M deficiency in monkey. Courtesy Dr. P. L. Day. 



cisors and may become so severe that the bone is exposed or the teeth fall 

 out. The gums are pale, and there are no marked spontaneous hemorrhages. 

 A photograph of the gingivitis in the terminal stages of an animal with nu- 

 tritional cytopenia is shown in Fig. 13. It was noted by Saslaw et al.^^ that 



" L. Wills and A. Stewart, Brit. J. Exptl. Pathol. 16, 444 (1935). 



58 W. C. Langston, W. J. Darby, C. F. Shukers, and P. L. Day, /. Exptl. Med. 68, 



923 (1938). 

 69 H. E. Wilson, C. A. Doan, S. Saslaw, and J. L. Schwab, Proc. Soc. Exptl. Biol. 



Med. 50, 341 (1942). 

 ^0 P. L. Day, W. C. Langston, and C. F. Shukers, /. Nutrition 9, 637 (1935). 

 ^^ O. D. Chapman and A. E. Harris, J. Infectious Diseases 69, 7 (1941). 

 «2 S. Saslaw, J. L. Schwab, O. C. Woolpert, and H. E. Wilson, Proc. Soc. Exptl. Biol. 



Med. 51, 391 (1942). 



