X. KKFKCrs or nKFIClKNCY 283 



(l('lici<'iic\' ill ;iiiiin;ils. The lo^ic ol such mikI simihir ;i(l('iii|)(s is ccilMiiily 

 ('\c(>(>(liiiu,iy thill, and it is no wondci- that the oltscrval ions reported were 

 \'(M"v coiitradiiiofy and apparently ol'teii marred by sul»,je('(i\-e factors, 

 enianaliiiu; either from the authors oi- I'loin the jxdients. 



One Li,r(Mi|) of such reports dealt with conditions iiuoKinj;' the neuro- 

 muscular system, such as myasthenia, ])arkinsonism, ch(jrea, epilepsy, 

 muscular dystrojiliy, and related (hseases. lieneficial results, claimed lifter 

 administration of pyi'idoxiiie in patients with muscular weakness,''*^ • '•^'^ in 

 some cases of parkinsonism,"^' "■* e\'en in poliomyelitis, in lifihtninj»; pains 

 accompanying talies dorsalis and in multiple sclerosis, wlien given intra- 

 spinally,'^^ or in chorea, '■'^' '^" and in hypertrophic muscular dystrophj'^''^'- '"- 

 may be contrasted with negative and, in general, better-controlled obser- 

 vations in parkinsonism, '^■*"'"° in muscular dystropliy,'^^''^" in amyotrophic 

 lateral sclerosis,*''*' ■ '" and in epilepsy. '^* 



The similarity of the cutaneous lesions in experimental pyridoxine de- 

 ficiency to des(iuamative and seborrheic or seborrheid lesions in man**^ 

 stimulated the use of pyridoxine in the therapy of this widely represented 

 clinical group of pathologic skin conditions. Negative results'^*- '^'* are 

 again to some extent matched with IxMieficial results in seborrheic or sebor- 

 rheid conditions after treatment with pyridoxine.'^*' "^^ 



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 '^3 .\. B. Baker, ./. Am. Med. Assoc. 116, 2484 (1941). 

 '*' M. .\. Zeligs, ./. Am. Med. Assoc. 116, 2148 (1941). 

 1" W. H. Barker, H. J. Stein, M. II. Miller, and M. .M. Winlrohc, Bull. Johns Hopkins 



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(1941). 

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16, 523 (1941). 

 '" A. McBryde and L. D. Baker, J. Pediat. 18, 727 (1941). 

 '" A. M. Doyle and II. H. Merritt, Arch. Neutrol. Physiai. 45, 672 (1941). 

 '«" A. M. Keith, J. Pedial. 20, 200 (1942). 

 '«' J. T. Fo.\ and G. M. Tullidge, Lancet II, 345 (1945). 

 '«2 P. Gyorgy, Arch. Dermatol, and Syphilid. 43, 230 (1941). 

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 '*' P. Gyorgy, unpuldished oi)servations. 



'«* N. JollifTe, L. A. Rosenl>lum, and J. Sawliill, J . Invest. Dermatol. 5, 143 (1942). 

 '«8 C. S. Wright, M. H. Samitz, and II. Brown, Arch. Dermatol, and Syphilol. 47, 651 



(1943). 



